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| 锟斤拷然锟斤拷锟斤拷锟斤拷锟绞★拷锟斤拷指锟斤拷锟斤拷药锟斤拷锟� |
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锟斤拷锟斤拷霉锟斤拷锟斤拷锟斤拷之锟斤拷锟�80锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟街匡拷锟斤拷锟截抵碉拷细锟斤拷锟斤拷锟斤拷袭锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷药锟斤拷锟斤拷锟斤拷涌锟街ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟结Э锟轿ｏ拷锟斤拷越锟剿诧拷为锟斤拷锟斤拷锟斤拷WHO锟斤拷锟狡ｏ拷锟斤拷2006锟斤拷锟斤拷锟�170锟斤拷锟斤拷锟斤拷锟节斤拷瞬锟斤拷锟酵憋拷锟斤拷锟揭╋拷锟斤拷锟绞癸拷锟斤拷锟矫癸拷锟斤拷锟叫э拷锟斤拷锟桔扣★拷锟斤拷锟斤拷锟斤拷锟斤拷药锟斤拷锟斤拷染锟斤拷效锟侥匡拷锟斤拷锟斤拷锟斤拷锟斤拷眉锟睫★拷
锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷细锟斤拷(myxobacteria)锟斤拷锟斤拷锟侥匡拷锟斤拷锟斤拷锟斤拷myxopyronin锟斤拷corallopyronin锟斤拷ripostatin锟斤拷锟斤拷惴猴拷锟阶拷锟斤拷锟斤拷锟斤拷锟斤拷芯锟斤拷校锟斤拷锟斤拷嵌园锟斤拷锟斤拷锟揭╋拷锟剿撅拷锟斤拷锟酵硷拷锟斤拷锟斤拷锟街斤拷锟缴拷锟斤拷锟斤拷锟斤拷(MRSA)锟斤拷锟节的讹拷锟斤拷细锟斤拷锟斤拷锟街筹拷锟斤拷强锟斤拷锟皆★拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷80—90锟斤拷锟斤拷捅锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷未锟斤拷探锟斤拷锟斤拷锟角的匡拷锟斤拷锟斤拷锟矫伙拷锟狡讹拷锟斤拷锟斤拷之锟竭革拷
要锟斤拷锟斤拷锟斤拷然锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷为锟斤拷锟剿癸拷锟较成碉拷药品锟斤拷锟斤拷锟斤拷锟斤拷饪拷锟斤拷锟斤拷锟斤拷牵锟斤拷锟斤拷锟斤拷锟轿癸拷锟斤拷锟斤拷锟斤拷药锟斤拷锟斤拷铜墙锟斤拷锟节ｏ拷锟斤拷锟秸ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷锟睫革拷斯锟斤拷学锟酵德癸拷锟秸讹拷姆锟斤拷锟侥革拷染锟叫撅拷锟斤拷锟侥的匡拷学锟揭筹拷锟斤拷锟斤拷示锟斤拷myxopyronin(myx)锟斤拷锟截碉拷锟斤拷锟斤拷位锟斤拷突锟斤拷疲锟轿拷锟斤拷诖锟斤拷锟斤拷锟饺伙拷锟斤拷屎铣晒锟斤拷赘锟叫э拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷票锟揭伙拷锟斤拷锟斤拷贸晒锟斤拷锟斤拷锟斤拷锟�2008锟斤拷10锟斤拷17锟秸的★拷细锟斤拷锟斤拷锟斤拷志锟较ｏ拷Cell 2008锟斤拷135(2)锟斤拷295锟斤拷锟斤拷
RNAP锟斤拷锟斤拷锟斤拷蟹钳状锟结构锟斤拷“蟹钳”锟斤拷围锟狡底诧拷“锟斤拷锟斤拷锟斤拷”锟斤拷锟斤拷30°锟斤拷转锟斤拷锟斤拷锟节闭猴拷(A)锟津开凤拷(B)状态锟斤拷“蟹钳”锟斤拷锟斤拷时锟斤拷锟斤拷DNA锟斤拷锟诫并锟斤拷呋锟斤拷锟斤拷锟斤拷锟�(C)锟斤拷然锟斤拷蘸辖锟紻NA锟截憋拷锟斤拷锟斤拷(D)锟斤拷锟斤拷时锟斤拷锟斤拷锟斤拷锟节合ｏ拷转录锟斤拷锟教匡拷始锟斤拷Myx 锟斤拷“锟斤拷锟斤拷锟斤拷”锟斤拷虾锟斤拷锟街�“蟹钳”锟斤拷锟脚ｏ拷使DNA锟斤拷锟杰斤拷锟�(E)锟斤拷
锟斤拷一锟斤拷 锟斤拷锟斤拷锟叫碉拷峁�
Myxopyronin锟斤拷corallopyronin锟斤拷ripostatin锟斤拷锟斤拷锟矫靶碉拷锟斤拷细锟斤拷锟斤拷RNA锟桔猴拷酶(RNAP)锟斤拷锟斤拷锟节匡拷锟斤拷锟斤拷锟叫凤拷锟斤拷员锟斤拷锟斤拷锟角革拷锟斤拷锟斤拷锟斤拷陌械恪ｏ拷锟斤拷龋锟斤拷锟斤拷锟斤拷糯锟阶硷拷锟斤拷锟斤拷斜锟斤拷锟斤拷酶锟斤拷锟斤拷细锟斤拷锟斤拷殖锟斤拷锟教的关硷拷一锟斤拷锟斤拷锟斤拷危锟絉NAP锟缴革拷锟斤拷锟角碉拷位锟斤拷锟缴ｏ拷锟杰匡拷锟杰帮拷锟斤拷锟斤拷锟叫★拷锟斤拷咏锟斤拷位锟姐。锟斤拷锟解，锟斤拷使锟斤拷锟筋保锟截碉拷锟角碉拷位锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷锟较革拷锟斤拷锟斤拷锟斤拷愎伙拷锟斤拷欤挂╋拷锟斤拷锟斤拷锟斤拷锟斤拷锟皆碉拷锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷
细锟斤拷RNAP锟斤拷蟹钳锟斤拷锟结构锟斤拷“蟹钳”锟斤拷时锟斤拷锟斤拷DNA锟斤拷锟诫并锟斤拷呋锟斤拷劢锟较ｏ拷然锟斤拷锟铰ｏ拷锟紻NA锟截憋拷锟斤拷锟节★拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷诤瞎锟斤拷锟酵憋拷锟斤拷校锟斤拷潭锟阶硷拷锟绞硷拷锟斤拷锟斤拷锟�“蟹钳”锟斤拷锟截的斤拷锟斤拷锟斤拷“锟斤拷锟斤拷锟斤拷”(switch region)锟斤拷锟斤拷锟斤拷搿�
锟节讹拷锟斤拷 锟斤拷锟斤拷锟斤拷锟轿伙拷锟�
锟叫撅拷锟斤拷筛选锟斤拷125锟斤拷锟斤拷myx锟襟肠杆撅拷锟斤拷锟疥，锟斤拷锟叫凤拷锟斤拷锟斤拷RNAP“锟斤拷锟斤拷锟斤拷”锟斤拷13锟斤拷锟斤拷锟截残伙拷锟斤拷锟斤拷锟斤拷锟轿猴拷一锟斤拷突锟斤拷锟斤拷苹锟絤yx锟斤拷希锟斤拷锟斤拷戮锟斤拷锟斤拷锟揭╋拷锟斤拷锟斤拷锟绞�“锟斤拷锟斤拷锟斤拷”锟斤拷myx锟侥斤拷喜锟轿伙拷锟絤yx通锟斤拷锟斤拷锟斤拷“蟹钳”锟侥匡拷锟较凤拷锟接变构效应锟斤拷锟斤拷锟斤拷一锟街诧拷同锟斤拷锟斤拷锟叫匡拷锟斤拷锟截的讹拷锟截伙拷锟狡★拷
锟斤拷趣锟斤拷锟角ｏ拷锟斤拷锟斤拷13锟斤拷锟叫伙拷锟节诧拷同细锟斤拷锟斤拷RNAP锟叫讹拷锟角憋拷锟斤拷(锟斤拷锟竭讹拷锟斤拷锟斤拷)锟侥ｏ拷锟斤拷锟斤拷越锟斤拷锟絤yx锟斤拷G+锟斤拷G-锟斤拷锟侥癸拷锟阶匡拷锟斤拷锟斤拷锟皆★拷锟斤拷锟斤拷3锟斤拷锟叫伙拷锟斤拷锟斤拷锟较革拷锟絉NAP锟叫诧拷锟斤拷锟截ｏ拷锟斤拷锟斤拷myx锟斤拷锟斤拷锟皆碉拷锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷
锟斤拷锟斤拷锟斤拷 探锟斤拷锟斤拷锟矫伙拷锟斤拷
锟斤拷一系锟斤拷锟斤拷锟斤拷锟叫撅拷锟叫ｏ拷锟叫撅拷锟竭凤拷锟街ｏ拷只锟斤拷锟饺硷拷myx锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟紻NA时锟斤拷myx锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟节合ｏ拷锟斤拷之锟斤拷没锟斤拷锟斤拷锟矫★拷锟斤拷锟揭ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷锟饺憋拷锟紻NA双锟斤拷锟斤拷锟斤拷myx也锟斤拷锟杰凤拷锟斤拷锟斤拷锟矫★拷锟斤拷锟斤拷示myx锟缴斤拷“蟹钳”锟斤拷锟斤拷锟节关闭伙拷锟截憋拷状态锟斤拷使之锟斤拷锟斤拷锟斤拷锟斤拷DNA双锟斤拷锟斤拷
Corallopyronin锟斤拷ripostatin锟斤拷锟斤拷锟斤拷模式锟斤拷锟斤拷锟斤拷myx锟斤拷锟狡★拷锟斤拷实锟较ｏ拷锟斤拷锟侥筹拷锟斤拷蟪Ω司锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟叫碉拷一锟斤拷锟斤拷药锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷也锟斤拷锟斤拷药锟斤拷
锟斤拷然锟斤拷锟斤拷锟斤拷目锟斤拷锟斤拷锟斤拷锟轿裁�“偏锟斤拷”锟斤拷锟斤拷RNAP锟斤拷锟叫癸拷锟斤拷谋锟斤拷位锟姐？锟金案诧拷锟矫讹拷知锟斤拷锟斤拷锟斤拷为RNAP锟斤拷同锟结构锟斤拷之锟斤拷墓亟冢锟斤拷锟叫┪伙拷锟斤拷锟斤拷恰锟狡匡拷锟斤拷锟叫碉拷锟窖缝，锟斤拷为锟斤拷锟斤拷锟斤拷锟节达拷锟斤拷谋锟斤拷锟斤拷锟斤拷凇锟�
锟矫成癸拷锟斤拷20锟斤拷锟斤拷细锟斤拷RNAP锟斤拷锟斤拷芯锟斤拷锟斤拷锟斤拷锟狡拷隆锟斤拷锟饺穖yx-RNAP锟结构锟斤拷锟斤拷锟矫伙拷锟狡猴拷锟斤拷锟角撅拷锟叫匡拷锟杰讹拷myx锟侥结构锟斤拷锟斤拷锟斤拷锟轿ｏ拷锟斤拷强锟斤拷锟斤拷RNAP锟斤拷锟阶猴拷锟斤拷锟斤拷锟斤拷锟斤拷效锟斤拷锟斤拷锟较成癸拷锟阶革拷效锟侥匡拷锟斤拷锟截ｏ拷使锟斤拷锟斤拷锟皆革拷染锟斤拷锟斤拷锟截伙拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷源锟斤拷锟叫癸拷医学锟斤拷坛锟斤拷 锟斤拷锟节ｏ拷
锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷
Cell锟斤拷锟斤拷Volume 135, Issue 2, 295-307, 17 October 2008锟斤拷Jayanta Mukhopadhyay, Eddy Arnold, Richard H. Ebright锟斤拷
