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| 锟角诧拷锟斤拷锟侥憋拷锟斤拷锟斤拷锟斤导锟铰革拷冒 |
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图1 锟斤拷染HRV锟斤拷viperin锟斤拷锟斤拷锟斤拷锟斤拷系锟�
图2 viperin锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷染时锟斤拷锟斤拷锟�
图3 锟斤拷锟斤拷viperin锟斤拷锟斤拷锟斤拷锝拷俳锟紿RV锟斤拷锟斤拷
锟斤拷锟斤拷一直锟斤拷为锟斤拷锟斤拷通锟斤拷冒锟斤拷锟缴鼻诧拷锟斤拷锟斤拷染锟斤拷锟斤拷模锟斤拷锟接︼拷谋锟斤拷锟斤拷锟斤拷锟斤拷纭拷锟斤拷锟饺革拷锟斤拷症状锟斤拷锟斤拷锟斤拷系统锟皆匡拷锟斤拷锟斤拷锟侥憋拷锟街★拷锟斤拷锟斤拷学锟竭斤拷锟秸凤拷锟街ｏ拷锟角诧拷锟斤拷锟斤拷染锟缴改憋拷锟斤拷锟斤拷锟节伙拷锟斤拷锟斤拷铮拷锟斤拷锟斤拷锟斤拷锟街⒆达拷姆锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟侥凤拷锟斤拷锟节★拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷症医学锟斤拷志锟斤拷(Am J Respir Crit Care Med 2008锟斤拷 178:962)锟较★拷
锟角诧拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷通锟斤拷冒锟斤拷锟斤拷要原锟斤拷
锟剿鼻诧拷锟斤拷(HRV)锟斤拷染锟斤拷锟斤拷通锟斤拷冒锟斤拷锟斤拷锟斤拷锟斤拷要原锟斤拷HRV锟斤拷染锟斤拷要锟斤拷锟斤拷锟节猴拷锟斤拷锟斤拷锟斤拷皮锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟叫诧拷锟斤拷锟斤拷染锟斤拷锟斤拷锟斤拷锟斤拷皮细锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷锟斤拷锟矫★拷锟叫硷拷说锟斤拷为锟斤拷锟斤拷锟斤拷锟侥憋拷锟斤拷锟斤拷皮细锟斤拷锟斤拷锟斤拷锟斤拷学锟斤拷锟皆ｏ拷锟接讹拷锟秸碉拷锟较猴拷锟斤拷锟斤拷锟斤拷症锟斤拷使锟矫革拷冒症状锟斤拷锟斤拷锟斤拷锟斤拷亍锟�
锟斤拷锟叫撅拷证锟斤拷锟斤拷锟斤拷染HRV锟斤拷锟斤拷皮细锟斤拷锟斤拷锟斤拷锟揭幌碉拷写锟斤拷椎锟较革拷锟斤拷锟斤拷雍锟斤拷锟斤拷锟斤拷锟斤拷印锟斤拷锟斤拷坪锟接≈わ拷锟斤拷锟斤拷锟斤拷锟剿碉拷锟斤拷锟斤拷锟饺綡RV锟斤拷锟斤拷皮细锟斤拷锟斤拷锟斤拷锟秸碉拷一些锟斤拷锟接诧拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷β锟斤拷锟斤拷锟斤拷2(β-defensin 2)锟斤拷锟秸碉拷锟斤拷一锟斤拷锟斤拷锟斤拷锟斤拷酶锟饺ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟侥凤拷锟斤拷锟斤拷应锟酵匡拷锟斤拷锟斤拷锟斤拷应锟斤拷锟斤拷锟斤拷HRV锟斤拷锟斤拷锟斤拷锟竭凤拷应锟侥撅拷锟斤拷锟斤拷锟侥壳帮拷圆锟斤拷锟斤拷锟斤拷
锟斤拷锟斤拷锟斤拷通锟剿ｏ拷HRV锟斤拷染锟斤拷锟杰诧拷锟斤拷锟斤拷锟斤拷太锟斤拷锟截碉拷锟斤拷锟解，锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟揭伙拷锟斤拷症状锟斤拷锟斤拷也锟酵筹拷锟斤拷一锟杰★拷锟斤拷锟斤拷锟节憋拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟皆肺硷拷锟斤拷(COPD)锟侥伙拷锟竭ｏ拷HRV锟斤拷染锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷泻锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷募锟斤拷苑锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟轿ｏ拷锟斤拷锟斤拷锟斤拷锟�
锟斤拷耍锟斤拷锟斤拷锟紿RV锟斤拷染锟侥撅拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷歉锟斤拷锟叫э拷锟斤拷锟斤拷聘锟矫帮拷锟揭诧拷砂锟斤拷锟紺OPD锟斤拷锟斤拷锟斤拷锟饺猴拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟竭癸拷芊锟斤拷铡锟�
锟角诧拷锟斤拷锟侥憋拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷
为锟剿斤拷一锟斤拷锟叫撅拷HRV锟斤拷染锟侥凤拷锟接伙拷锟狡ｏ拷锟斤拷锟皆硷拷锟矫大卡讹拷锟斤拷锟斤拷(Calgary)锟斤拷学锟斤拷锟斤拷锟酵碉拷(Proud)锟斤拷锟斤拷微锟斤拷锟斤拷(microarray)锟斤拷锟斤拷锟斤拷锟斤拷烁锟饺綡RV锟竭的猴拷锟斤拷锟斤拷锟斤拷皮细锟斤拷锟斤拷锟斤拷锟斤拷HRV锟斤拷染锟缴改憋拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟侥憋拷锟斤，锟斤拷些锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟竭凤拷应锟斤拷兀锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷雍涂锟斤拷锟斤拷锟斤拷锟斤拷椎牟锟斤拷锟斤拷取锟�
锟斤拷前瞻锟皆★拷锟斤拷锟斤拷锟斤拷芯锟斤拷锟斤拷锟斤拷锟�35锟斤拷志愿锟竭ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟饺撅拷锟斤拷锟斤拷锟斤拷锟�(锟街憋拷注锟斤拷HRV-16锟斤拷慰锟斤拷)锟斤拷锟斤拷注锟斤拷前锟斤拷锟斤拷直锟饺★拷锟斤拷锟斤拷皮细锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷
注锟戒病锟斤拷锟侥诧拷锟斤拷锟竭讹拷锟斤拷锟斤拷锟剿革拷冒症状锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟绞撅拷锟斤拷诟锟饺撅拷锟�8小时锟斤拷锟斤拷锟斤拷锟斤拷锟阶达拷锟斤拷锟斤拷锟斤拷时锟斤拷炔锟斤拷薷谋洹ｏ拷锟斤拷诟锟饺撅拷锟斤拷2锟届，注锟戒病锟斤拷锟竭憋拷腔锟斤拷皮细锟斤拷锟节达拷锟斤拷6530锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷(discrete genes)锟斤拷11887锟斤拷锟斤拷锟斤拷转录锟斤拷锟斤拷(gene transcripts)锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷臁�
锟斤拷锟斤拷些锟斤拷锟斤发锟斤拷锟戒化锟侥伙拷锟斤拷锟叫ｏ拷锟叫撅拷锟竭凤拷锟街ｏ拷471锟斤拷转录锟斤拷锟斤拷锟斤拷锟斤拷系锟斤拷锟斤拷锟�2锟斤拷锟斤拷201锟斤拷转录锟斤拷锟斤拷锟斤拷锟斤拷碌锟斤拷锟�50%锟斤拷锟揭★拷锟斤拷锟斤拷锟较碉拷锟侥伙拷锟斤拷要么锟斤拷锟斤拷募锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟接ｏ拷要么锟秸碉拷锟斤拷锟斤拷锟截诧拷锟斤拷锟斤拷锟斤拷锟斤拷一锟斤拷锟街可诧拷锟斤拷锟斤拷HRV锟斤拷锟杰的碉拷锟阶ｏ拷锟斤拷锟斤拷2锟斤拷5-锟斤拷锟斤拷锟斤拷锟斤拷锟矫革拷锟斤拷锟斤拷约锟絭iperin(锟斤拷锟斤拷锟斤拷锟竭讹拷锟斤拷锟斤拷)锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟较碉拷锟侥伙拷锟斤拷锟斤拷细锟斤拷锟斤拷锟接和诧拷锟斤拷锟脚猴拷转锟斤拷锟斤拷锟斤拷锟皆硷拷细锟斤拷锟斤拷锟斤拷锟斤拷亍锟�
锟斤拷之锟斤拷龋锟斤拷蟛糠直锟斤拷锟斤拷碌锟斤拷幕锟斤拷锟斤拷懿锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟街拷锟接︼拷薰氐锟斤拷锟斤拷濉�
锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷viperin锟斤拷锟斤拷锟斤拷锟斤拷锟�
锟斤拷前锟斤拷锟叫撅拷锟斤拷锟芥，viperin锟叫匡拷锟斤拷锟斤拷锟斤拷锟皆ｏ拷锟斤拷锟斤拷锟紿RV锟斤拷锟狡碉拷影锟斤拷锟叫诧拷锟斤拷锟斤拷锟斤拷芯锟斤拷呓锟揭伙拷锟斤拷锟斤拷锟斤拷锟絭iperin锟斤拷HRV锟斤拷染锟侥癸拷系锟斤拷锟斤拷锟斤拷viperin锟斤拷锟斤拷锟斤拷锟斤拷氩匡拷指锟矫爸⒆�(锟斤拷漏锟斤拷锟斤拷锟斤拷秃锟斤拷锟�)锟斤拷锟斤拷锟斤拷锟�(P<0.05)锟斤拷
锟斤拷锟解，锟斤拷锟斤拷然锟斤拷锟斤拷HRV锟斤拷染锟斤拷锟斤拷症状锟竭的憋拷锟斤拷皮细锟斤拷锟叫ｏ拷viperin锟斤拷锟斤拷锟斤拷锟绞癸拷锟斤拷呛锟斤拷锟�(mRNA)锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷(P<0.01)(图1)锟斤拷
为锟斤拷证实HRV锟斤拷染锟斤拷使viperin锟斤拷锟斤拷锟斤拷锟斤拷皮细锟斤拷锟叫的憋拷锟斤拷锟较碉拷锟斤拷锟叫撅拷锟斤拷锟斤拷HRV锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟铰革拷染锟斤拷原锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷支锟斤拷锟斤拷锟斤拷皮(HBE)细锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷郑锟紿RV-16锟斤拷染锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟侥★拷锟斤拷染时锟斤拷锟斤拷锟斤拷锟斤拷viperin锟斤拷锟斤拷锟斤拷锟斤拷系锟斤拷锟斤拷诨锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷拢锟紿BE细锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷viperin锟斤拷锟津。达拷HRV-16锟斤拷染锟斤拷锟�12小时锟斤拷48小时锟斤拷HBE细锟斤拷锟斤拷viperin锟斤拷锟斤拷mRNA锟侥猴拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷(P<0.02)(图2)锟斤拷
通锟斤拷小锟斤拷锟脚猴拷锟角猴拷锟斤拷(siRNA)锟侥伙拷锟斤拷锟斤拷锟斤拷(knockdown)锟斤拷锟斤拷锟斤拷锟叫撅拷锟竭凤拷锟街ｏ拷锟斤拷锟斤拷viperin锟斤拷锟斤拷谋锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷HRV锟侥革拷锟斤拷(P<0.02)(图3)锟斤拷锟接讹拷证实锟斤拷viperin锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷HRV锟斤拷锟斤拷锟叫碉拷锟斤拷锟矫★拷
锟斤拷锟狡革拷冒锟斤拷锟斤拷思路
锟斤拷去锟斤拷锟斤拷锟斤拷为锟斤拷锟斤拷冒锟斤拷一系锟斤拷症状锟斤拷锟斤拷锟斤拷系统锟斤拷锟斤拷锟侥憋拷锟街★拷锟剿达拷锟叫撅拷锟斤拷通锟斤拷锟斤拷HRV锟斤拷染锟斤拷锟斤拷锟斤拷锟叫撅拷锟斤拷锟斤拷锟街该诧拷锟斤拷锟斤拷染锟缴改憋拷一系锟叫伙拷锟斤拷谋锟斤拷铩ｏ拷锟斤拷校锟絭iperin锟斤拷锟斤拷谋锟斤拷锟斤拷锟斤拷锟斤拷诤锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷戮锟斤拷锟斤拷系锟斤拷锟斤拷锟斤拷系锟斤拷锟斤拷锟斤拷锟斤拷锟紿RV锟斤拷染锟斤拷时锟斤拷锟接筹拷锟斤拷锟斤拷锟接★拷锟斤拷锟斤拷viperin锟斤拷锟斤拷谋锟斤拷锝拷俳锟紿RV锟斤拷锟斤拷锟斤拷锟节的革拷锟狡★拷
锟叫撅拷锟斤拷锟斤拷为锟斤拷锟剿次的凤拷锟街斤拷示锟斤拷HRV锟斤拷染锟斤拷锟斤拷锟斤拷锟斤拷锟接︼拷锟揭诧拷业锟斤拷锟揭恍╋拷碌幕锟斤拷锟斤拷舛硷拷锟斤拷锟轿拷锟斤拷锟斤拷锟狡革拷冒锟斤拷锟斤拷碌锟剿悸凤拷锟�
锟斤拷染HRV锟斤拷使锟斤拷锟斤拷锟斤拷viperin锟斤拷锟斤拷谋锟斤拷锟斤拷系锟斤拷锟斤拷锟斤拷系锟斤拷锟斤拷锟斤拷锟紿RV锟斤拷染时锟斤拷锟斤拷兀锟斤拷诟锟饺撅拷锟�48小时锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絭iperin锟斤拷锟斤拷谋锟斤拷锝拷锟斤拷锟斤拷锟斤拷锟紿RV锟斤拷锟斤拷锟斤拷锟节的革拷锟狡ｏ拷锟斤拷示viperin锟节对匡拷HRV锟斤拷染锟斤拷锟斤拷锟斤拷要锟斤拷锟矫★拷锟斤拷锟斤拷源锟斤拷锟叫癸拷医学锟斤拷坛锟斤拷 锟斤拷锟脚ｏ拷
锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷症医学锟斤拷志锟斤拷(
Am J Respir Crit Care Med)锟斤拷Vol 178. pp. 962-968, (2008)锟斤拷David Proud锟斤拷Jeffrey W. Clymer锟斤拷
