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血锟斤拷锟斤拷皮锟斤拷锟斤拷锟斤拷锟斤拷(VEGF)锟斤拷锟藉贝锟斤拷锟斤拷锟斤拷锟斤拷锟叫匡拷锟斤拷锟斤拷锟斤拷锟斤拷血锟斤拷锟斤拷锟斤拷锟斤拷锟矫ｏ拷锟斤拷锟斤拷效锟斤拷锟狡斤拷直锟斤拷锟斤拷锟斤拷锟斤拷小细锟斤拷锟轿帮拷(NSCLC)锟斤拷锟斤拷细锟斤拷锟斤拷锟皆硷拷锟斤拷锟劫帮拷锟饺讹拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟劫达拷应锟斤拷越锟斤拷越锟斤拷之锟绞ｏ拷锟斤拷锟斤拷锟斤拷医学协锟斤拷锟节匡拷锟斤拷锟斤拷JAMA 锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟揭伙拷锟斤拷锟斤拷头锟斤拷锟斤拷疲锟斤拷锟斤拷芨锟揭╋拷锟斤拷频陌锟街拷锟斤拷呔锟斤拷锟窖ㄋ拷锟�(VTE)危锟斤拷锟斤拷锟斤拷锟斤拷锟接★拷锟斤拷症锟斤拷锟竭憋拷锟斤拷锟酵达拷锟节较高碉拷VTE危锟秸ｏ拷锟斤拷锟斤拷俅锟揭绞︼拷锟斤拷锟斤拷卟锟斤拷懿锟斤拷源锟斤拷锟斤拷怨锟阶拷锟�
锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟狡的诧拷锟斤拷锟斤拷应锟叫ｏ拷锟斤拷锟斤拷确锟侥帮拷锟斤拷锟斤拷锟斤拷血栓栓锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷VTE却锟斤拷锟斤拷锟斤拷锟介。锟斤拷锟斤拷纽约斯锟斤拷锟结布鲁锟剿达拷学锟斤拷锟斤拷鲁锟斤拷(Nalluri)锟饺匡拷展锟斤拷锟斤拷锟斤拷锟酵凤拷锟斤拷锟斤拷目锟侥撅拷锟斤拷为锟斤拷锟斤拷锟桔憋拷锟斤拷锟斤拷锟斤拷锟斤拷锟狡碉拷VTE锟斤拷锟斤拷危锟秸★拷
Nalluri锟饺硷拷锟斤拷锟斤拷PubMed锟酵匡拷学锟斤拷锟斤拷(Web of Science)锟斤拷锟斤拷锟捷匡拷(1966锟斤拷1锟斤拷锟斤拷2008锟斤拷1锟斤拷)锟皆硷拷锟斤拷锟斤拷锟劫达拷锟斤拷锟斤拷学锟斤拷(ASCO)锟斤拷锟斤拷摘要(2000锟斤拷1锟斤拷锟斤拷2008锟斤拷1锟斤拷)锟斤拷锟斤拷锟斤拷锟斤拷15锟斤拷锟斤拷锟斤拷锟斤拷锟绞碉拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟叫撅拷(7956锟斤拷锟斤拷锟斤拷)锟斤拷锟叫凤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷频锟絍TE锟斤拷锟斤拷锟斤拷VTE锟斤拷锟斤拷锟绞分憋拷为11.9%锟斤拷6.3%;锟斤拷锟斤拷锟斤拷锟斤拷锟饺ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷VTE危锟斤拷锟斤拷锟斤拷锟斤拷锟竭ｏ拷锟斤拷锟斤拷锟轿ｏ拷锟�(RR)为1.33(P<0.001)锟斤拷
锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷为锟轿会导锟斤拷VTE危锟斤拷?Nalluri锟饺凤拷锟斤拷锟斤拷锟斤拷锟斤拷锟皆拷锟斤拷锟斤拷:锟斤拷锟斤拷VEGF锟秸碉拷锟斤拷锟斤拷皮锟斤拷锟斤拷锟斤拷使锟斤拷皮锟铰达拷锟斤拷锟斤拷脂锟斤拷露;锟斤拷锟斤拷一锟斤拷锟斤拷锟斤拷锟斤拷前锟叫伙拷锟斤拷锟斤拷锟斤拷;使锟斤拷锟斤拷锟酵放达拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷;锟较碉拷锟斤拷锟斤拷症细锟斤拷锟斤拷锟接憋拷锟斤，锟斤拷锟斤拷锟狡わ拷锟斤拷撕锟皆凰拷锟斤拷锟斤拷傻取锟�
1锟斤拷锟斤拷前锟斤拷锟斤拷锟斤拷学锟斤拷也锟斤拷锟斤拷锟斤拷锟斤拷锟狡碉拷锟斤拷锟酵凤拷锟斤拷锟斤拷锟斤拷锟斤拷锟节★拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷症锟叫撅拷锟斤拷锟斤拷志锟斤拷[J Natl Cancer Inst 2007锟斤拷 99(16): 1232]锟斤拷锟斤拷锟斤拷为锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟较伙拷锟狡诧拷锟斤拷锟斤拷锟斤拷VTE危锟秸★拷锟斤拷锟角ｏ拷Nalluri锟斤拷锟斤拷为锟矫凤拷锟斤拷锟斤拷锟斤拷锟叫撅拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷太锟斤拷(5锟筋，1745锟斤拷锟斤拷锟斤拷)锟斤拷锟剿猴拷锟斤拷锟叫达拷锟斤拷锟斤拷锟节憋拷锟斤拷锟斤拷锟斤拷锟斤拷锟叫撅拷锟斤拷锟捷癸拷锟斤拷锟斤拷锟斤拷烁梅锟斤拷锟轿达拷锟斤拷锟绞碉拷锟接筹拷锟斤拷锟斤拷锟斤拷锟斤拷锟絍TE危锟秸★拷锟斤拷锟斤拷锟斤拷锟斤拷锟角碉拷锟斤拷锟斤拷锟斤拷锟酵凤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷药品锟斤拷装锟较匡拷锟斤拷锟斤拷要锟斤拷锟斤拷锟斤拷应锟侥黑框警告，锟斤拷锟斤拷锟斤拷锟劫达拷医师锟斤拷锟斤拷锟竭对达拷危锟斤拷锟斤拷呔锟斤拷瑁拷锟斤拷锟斤拷锟角★拷锟斤拷募锟截和达拷锟斤拷锟斤拷
Nalluri锟斤拷锟斤拷锟斤拷锟剿憋拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絍TE锟侥匡拷锟斤拷危锟斤拷锟斤拷锟截★拷锟斤拷锟角凤拷锟街ｏ拷锟斤拷症锟斤拷锟酵匡拷锟斤拷影锟斤拷VTE锟斤拷锟斤拷锟绞ｏ拷锟斤拷直锟斤拷锟斤拷锟斤拷锟竭凤拷锟斤拷锟斤拷锟斤拷锟�(19.1%)锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟�(3%)锟斤拷NSCLC锟斤拷锟斤拷锟劫帮拷锟斤拷锟竭撅拷锟斤拷(锟街憋拷为14.9%锟斤拷7.3%)锟斤拷锟斤拷锟斤拷锟斤拷为锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷危锟斤拷症锟斤拷锟竭ｏ拷应锟矫憋拷锟斤拷锟斤拷锟斤拷时锟叫憋拷要锟斤拷锟斤拷预锟斤拷锟皆匡拷锟斤拷锟斤拷锟狡★拷锟脚猴拷锟斤拷锟角ｏ拷锟斤拷锟斤拷锟斤拷未锟斤拷锟揭碉拷锟斤拷锟斤拷锟斤拷危锟斤拷锟斤拷锟截★拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷药锟斤拷锟斤拷锟斤拷锟狡猴拷锟斤拷VTE危锟斤拷也锟斤拷影锟届，锟斤拷锟斤拷锟斤拷影锟斤拷太小锟接讹拷锟睫凤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟�2.5 mg/kg锟斤拷5.0 mg/kg锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟狡碉拷VTE危锟秸撅拷锟斤拷锟斤拷锟斤拷锟节讹拷锟斤拷锟介。为锟斤拷锟斤拷锟斤拷锟斤拷锟街革拷危锟酵碉拷危锟斤拷锟竭ｏ拷锟叫憋拷要锟斤拷一锟斤拷锟斤拷确VTE危锟斤拷锟斤拷锟截★拷
围锟斤拷锟斤拷锟斤拷锟斤拷锟酵凤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟绞匡拷追妆锟斤拷锟斤拷锟斤拷约锟斤拷墓鄣恪�
锟斤拷锟斤拷医学锟斤拷站Medscape专锟揭癸拷锟绞★拷印锟节帮拷锟缴达拷学锟斤拷症锟斤拷锟侥碉拷斯锟斤拷锟斤拷(Sledge)指锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟剿感碉拷锟截憋拷锟斤拷锟解，锟斤拷为锟斤拷锟斤拷锟斤拷锟斤拷锟较撅拷锟斤拷锟斤拷锟斤拷锟斤拷血锟杰碉拷药锟斤。锟斤拷锟角ｏ拷锟矫斤拷锟斤拷锟饺伙拷锟斤拷锟斤拷卮锟斤拷锟劫达拷锟斤拷锟藉，锟斤拷锟斤拷锟斤拷锟节帮拷症锟斤拷锟竭憋拷锟斤拷锟窖撅拷锟斤拷VTE锟斤拷危锟斤拷群锟斤拷前锟斤拷锟铰★拷
锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟矫斤拷锟斤拷锟斤拷锟斤拷峁╋拷牟锟狡凤拷锟饺拷锟斤拷喜锟斤拷蕹锟斤拷耄拷锟街拷锟斤拷锟斤拷锟斤拷鄄锟饺★拷锟斤拷锟斤拷锟斤拷疲锟斤拷锟斤拷锟斤拷芊锟斤拷锟絍TE锟斤拷一锟斤拷通锟斤拷锟斤拷锟斤拷锟斤拷锟狡讹拷锟杰斤拷锟斤拷锟�
锟矫斤拷锟揭诧拷锟斤拷锟斤拷锟斤拷锟斤拷锟�2007锟斤拷锟斤拷锟酵凤拷锟斤拷锟竭碉拷注锟解。锟斤拷锟斤拷锟脚克达拷学医学锟斤拷锟侥的猴拷维锟斤拷(Hurwitz)锟睫筹拷锟劫达拷医师应锟矫撅拷锟斤拷VTE潜锟斤拷危锟秸ｏ拷锟斤拷锟斤拷注锟解到锟斤拷锟斤拷锟絍TE锟铰硷拷锟斤拷锟斤拷锟斤拷锟竭猴拷锟劫★拷锟斤拷锟节憋拷锟斤拷锟斤拷锟斤拷锟斤拷锟絍TE锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷确锟侥匡拷锟斤拷锟斤拷锟斤拷锟斤拷应证锟斤拷目前锟皆诧拷应锟斤拷锟介常锟斤拷锟斤拷锌锟斤拷锟斤拷锟斤拷疲锟斤拷锟斤拷乜锟皆わ拷锟斤拷钥锟斤拷锟斤拷锟斤拷锟街革拷锟斤拷锟绞碉拷锟斤拷希锟斤拷锟斤拷诎锟街拷锟斤拷锟斤拷械锟皆わ拷锟斤拷钥锟斤拷锟斤拷锟斤拷锟斤拷锟侥壳帮拷锟斤拷锟窖э拷锟斤拷锟斤拷锟斤拷鹊锟街伙拷锟街碉拷媒锟揭伙拷锟斤拷锟斤拷锟教斤拷帧锟斤拷锟斤拷锟皆达拷锟斤拷泄锟揭窖э拷锟教筹拷锟� 锟斤拷锟斤拷楼锟斤拷
锟斤拷锟斤拷锟斤拷锟斤拷医学协锟斤拷锟节匡拷锟斤拷锟斤拷
JAMA 锟斤拷锟斤拷2008;300(19):2277-2285锟斤拷Shobha Rani Nalluri锟斤拷Shenhong Wu锟斤拷
