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锟斤拷锟斤拷锟结环锟斤拷酶锟斤拷锟藉（rGC锟斤拷锟酵匡拷锟斤拷锟斤拷锟斤拷锟斤拷锟结环锟斤拷酶锟斤拷sGC锟斤拷锟斤拷一锟斤拷峁�
锟街诧拷锟杰巴斤拷转锟斤拷锟角斤拷直锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷要预锟斤拷锟斤拷锟截ｏ拷锟叫局诧拷锟杰巴斤拷转锟斤拷锟竭的革拷锟斤拷锟绞高达拷50%锟斤拷然锟斤拷锟斤拷锟斤拷使锟角诧拷锟斤拷锟节局诧拷锟杰巴斤拷转锟狡碉拷pN0锟斤拷直锟斤拷锟斤拷锟斤拷锟竭ｏ拷锟斤拷锟斤拷锟斤拷也锟竭达拷25%锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷斯·锟斤拷锟窖凤拷锟絋omas Jefferson锟斤拷锟斤拷学锟竭讹拷锟斤拷锟斤拷锟斤拷Waldman锟斤拷锟饺碉拷锟斤拷锟叫撅拷锟揭匡拷锟斤拷锟斤拷锟叫的帮拷锟截ｏ拷pN0锟斤拷锟斤拷锟斤拷锟斤拷锟杰巴斤拷没锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷锟斤拷实锟较ｏ拷87.5%锟斤拷pN0锟斤拷直锟斤拷锟斤拷锟斤拷锟竭达拷锟斤拷“锟杰巴斤拷锟斤拷锟斤拷锟斤拷转锟斤拷”锟斤拷锟斤拷锟斤拷锟斤拷锟结环锟斤拷酶2C锟斤拷GUCY2C锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟叫讹拷锟斤拷锟斤拷锟斤拷转锟狡达拷锟斤拷锟斤拷锟斤拷一锟斤拷锟斤拷效指锟疥。
Waldman锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟窖э拷锟斤拷锟斤拷氪筹拷姆锟斤拷诜锟斤拷锟斤拷锟斤拷希锟揭伙拷锟斤拷锟缴革拷锟矫碉拷细锟斤拷pN0锟斤拷锟竭ｏ拷锟斤拷锟斤拷锟斤拷锟轿ｏ拷战细锟斤拷撸锟斤拷锟揭伙拷锟斤拷锟揭诧拷锟斤拷锟斤拷锟街革拷锟斤拷锟斤拷疲锟斤拷械姆锟绞革拷馗锟斤拷韪拷锟斤拷锟斤拷啤锟斤拷锟斤拷芯锟斤拷锟斤拷锟斤拷锟�2锟斤拷18锟秸的★拷锟斤拷锟斤拷医学锟斤拷锟斤拷志锟斤拷锟斤拷JAMA 锟斤拷锟较★拷
锟斤拷锟脚筹拷pN0锟斤拷锟竭达拷锟斤拷锟杰巴斤拷锟斤拷锟斤拷锟斤拷转锟斤拷
GUCY2C锟斤拷一锟街碉拷锟轿匡拷膜锟斤拷锟斤拷锟斤拷锟藉，锟斤拷锟斤拷锟斤拷为锟斤拷锟秸碉拷锟阶猴拷锟斤拷锟斤拷锟秸碉拷锟阶★拷锟节结肠锟斤拷锟斤拷锟斤拷锟斤拷诮锥危锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟侥憋拷锟斤拷缺失锟斤拷锟斤拷突岬硷拷锟紾UCY2C锟脚号癸拷锟斤拷锟斤拷锟揭ｏ拷锟教讹拷锟铰帮拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷GUCY2C锟斤拷锟斤拷锟斤，锟斤拷映锟斤拷锟斤拷锟斤拷锟藉被锟斤拷锟斤拷锟斤拷锟斤拷锟藉超锟斤拷锟斤拷锟斤拷锟矫ｏ拷锟斤拷示GUCY2C锟斤拷一锟斤拷锟斤拷锟斤拷锟皆凤拷锟接憋拷志锟斤。
锟斤拷前瞻锟斤拷锟叫撅拷锟斤拷锟斤拷锟斤拷2002锟斤拷3锟斤拷锟斤拷2007锟斤拷6锟铰碉拷257锟斤拷0锟斤拷锟斤拷锟斤拷pN0锟斤拷直锟斤拷锟斤拷锟斤拷锟竭ｏ拷通锟斤拷锟斤拷锟斤拷锟斤拷转录-锟桔猴拷酶锟斤拷锟斤拷应锟斤拷RT-PCR锟斤拷锟斤拷锟斤拷锟斤拷锟饺★拷锟斤拷锟叫╋拷锟斤拷叩锟�2570枚直锟斤拷≥5 mm锟斤拷锟斤拷锟杰巴结（1锟斤拷33枚/锟斤拷锟斤拷锟斤拷位锟斤拷为8枚/锟斤拷锟斤拷锟斤拷GUCY2C锟斤拷锟斤拷锟斤拷锟斤拷锟�
锟斤拷锟斤拷锟绞撅拷锟�32锟斤拷锟斤拷12.5%锟斤拷pN0锟斤拷直锟斤拷锟斤拷锟斤拷锟斤拷锟杰巴斤拷GUCY2C锟斤拷锟轿拷锟斤拷裕锟轿猵N0 锟斤拷mol-锟斤拷锟斤拷锟捷达拷锟叫讹拷锟戒不锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷转锟狡ｏ拷锟斤拷锟斤拷225锟斤拷锟斤拷87.5%锟斤拷锟斤拷锟竭碉拷1枚锟斤拷锟斤拷锟矫讹拷馨徒岜伙拷锟斤拷GUCY2C锟斤拷锟皆ｏ拷为pN0锟斤拷mol+锟斤拷锟斤拷锟叫讹拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟阶拷啤锟�
rGC锟缴帮拷锟斤拷峁癸拷锟紼CD锟斤拷锟斤拷锟斤拷膜片锟轿ｏ拷TM锟斤拷锟斤拷锟斤拷酶同源锟结构锟斤拷KHD锟斤拷锟斤拷锟斤拷锟斤拷-锟斤拷锟斤拷锟结构锟斤拷CCD锟斤拷锟斤拷锟斤拷锟斤拷锟结环锟斤拷酶锟结构锟斤拷GC锟斤拷锟斤拷锟斤拷sGC锟斤拷血锟斤拷锟截结构锟斤拷HD锟斤拷锟斤拷CCD锟斤拷GC锟斤拷锟斤拷
锟斤拷锟斤拷学锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷转锟斤拷“锟睫可讹拷锟斤拷”
锟斤拷统锟侥凤拷锟节凤拷锟斤拷锟斤拷要锟斤拷锟斤拷锟斤拷织锟斤拷锟斤拷学锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷要锟斤拷锟斤拷锟节ｏ拷锟劫斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟杰巴斤拷锟斤拷蟹锟斤拷锟斤拷锟斤拷锟斤拷锟铰╋拷锟斤拷锟斤拷馨徒幔伙拷诮锟斤拷锟斤拷锟斤拷锟斤拷馨徒锟斤拷锟斤拷锟斤拷锟杰帮拷锟斤拷织锟斤拷锟叫凤拷锟斤拷锟斤拷锟斤拷锟斤拷漏锟斤拷锟斤拷细锟斤拷锟斤拷锟斤拷锟斤拷织锟斤拷锟斤拷学锟斤拷楸撅拷锟斤拷锟斤拷锟斤拷锟斤拷缘停锟斤拷锟街憋拷锟斤拷锟斤拷呓锟轿拷锟�200锟斤拷锟斤拷锟斤拷细锟斤拷锟叫硷拷锟�1锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷
锟斤拷锟斤拷学锟斤拷锟斤拷锟津不碉拷锟缴斤拷锟斤拷锟叫可得碉拷锟斤拷锟斤拷织锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷愿撸锟斤拷锟绞癸拷锟�100锟斤拷锟斤拷锟斤拷锟较革拷锟斤拷锟斤拷锟�1锟斤拷锟斤拷锟斤拷细锟斤拷也锟缴硷拷锟斤拷锟斤拷锟饺伙拷锟斤拷锟斤拷锟窖э拷锟斤拷锟斤拷锟揭拷锟斤拷锟斤拷诩锟斤拷锟斤拷锟斤拷锟斤拷苑锟斤拷颖锟街撅拷铩ｏ拷锟斤拷锟斤拷锟斤拷芯锟斤拷校锟紾UCY2C锟斤拷锟斤拷pN0锟斤拷直锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟皆凤拷锟接憋拷志锟斤。锟斤拷然锟斤拷锟斤拷锟斤拷锟叫撅拷锟斤拷锟斤拷锟绞憋拷浠癸拷锟斤拷锟斤拷锟斤拷锟斤拷锟揭拷锟斤拷锟斤拷锟斤拷锟叫撅拷锟斤拷锟斤拷锟斤拷酶锟斤拷锟绞憋拷锟斤拷锟叫撅拷锟斤拷锟斤拷锟斤拷准锟斤拷锟斤拷锟斤拷GUCY2C锟斤拷锟斤拷RT-PCR锟斤拷锟斤拷预锟斤拷锟街碉拷锟�
锟斤拷锟斤拷学锟斤拷锟节碉拷锟斤拷一锟斤拷锟矫达拷锟斤拷锟斤拷指锟斤拷锟斤拷锟狡★拷锟斤拷锟斤拷锟斤拷锟狡对拷锟节斤拷直锟斤拷锟斤拷锟斤拷锟竭碉拷锟斤拷锟斤拷锟芥处锟窖撅拷锟饺斤拷锟斤拷确锟斤拷锟斤拷锟斤拷锟节拷锟斤拷pN0锟斤拷锟竭ｏ拷一些锟叫撅拷锟斤拷示锟斤拷锟斤拷锟斤拷锟斤拷锟芥处锟斤拷锟斤拷一些却锟斤拷示没锟叫ｏ拷原锟斤拷锟斤拷冢锟斤拷馨徒锟斤拷锟斤拷锟斤拷锟阶拷频拇锟斤拷诳锟斤拷懿锟斤拷只卮锟斤拷烁锟斤拷锟斤拷狻ｏ拷锟饺籶N0锟斤拷mol+锟斤拷锟斤拷锟竭的革拷锟斤拷锟斤拷锟斤拷锟斤拷锟节拷锟斤拷pN1锟斤拷锟竭ｏ拷锟斤拷么锟斤拷痈锟斤拷锟斤拷锟斤拷锟斤拷械幕锟斤拷锟揭诧拷锟斤拷锟斤拷锟斤拷锟斤拷诤锟斤拷摺锟斤拷锟斤拷锟斤拷希锟�
锟杰巴斤拷GUCY2C锟斤拷锟斤拷预示pN0锟斤拷直锟斤拷锟斤拷锟斤拷锟斤拷危锟斤拷
锟叫撅拷锟竭讹拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟�2锟斤拷63锟斤拷锟铰ｏ拷锟斤拷位锟斤拷锟绞憋拷锟轿�24锟斤拷锟铰ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷同GUCY2C锟斤拷锟斤拷锟竭的硷拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟�87锟斤拷锟斤拷锟斤拷pN1锟斤拷锟竭斤拷锟斤拷锟剿比较★拷
锟斤拷锟斤拷锟绞撅拷锟�32锟斤拷pN0锟斤拷mol-锟斤拷锟斤拷锟斤拷锟叫斤拷锟斤拷2锟斤拷锟斤拷6.3%锟斤拷锟斤拷锟斤拷锟斤拷诩涓达拷锟斤拷锟街碉拷锟揭伙拷锟斤拷锟角ｏ拷锟斤拷2锟斤拷锟斤拷锟竭斤拷锟斤拷GUCY2C锟斤拷锟斤拷锟杰巴结都锟角筹拷锟劫ｏ拷锟街憋拷为1枚锟斤拷2枚锟斤拷锟斤拷锟斤拷也锟斤拷某锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷示锟斤拷一锟街凤拷锟节硷拷锟斤拷锟斤拷锟斤拷要锟斤拷锟姐够锟斤拷锟斤拷锟斤拷锟侥伙拷锟斤拷锟较斤拷锟叫诧拷锟叫匡拷锟杰革拷锟斤拷准锟斤拷
225锟斤拷pN0锟斤拷mol+锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷47锟斤拷锟斤拷20.9%锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟绞诧拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷pN0锟斤拷mol-锟斤拷锟斤拷锟竭ｏ拷P=0.006锟斤拷锟斤拷锟斤拷锟斤拷锟窖撅拷锟接斤拷锟斤拷锟斤拷pN1锟斤拷锟竭★拷
锟斤拷锟斤拷锟截凤拷锟斤拷锟斤拷示锟斤拷锟杰巴斤拷GUCY2C锟斤拷锟斤拷锟斤拷pN0锟斤拷直锟斤拷锟斤拷锟斤拷锟竭的讹拷锟斤拷预锟斤拷锟斤拷锟截ｏ拷pN0锟斤拷mol+锟斤拷锟斤拷锟竭革拷锟斤拷锟斤拷锟斤拷[校锟斤拷锟斤拷锟秸比ｏ拷HR锟斤拷为4.66锟斤拷P=0.04]锟斤拷锟睫诧拷锟斤拷锟斤拷锟绞较低ｏ拷校锟斤拷HR为3.27锟斤拷P=0.03锟斤拷锟斤拷锟斤拷锟斤拷源锟斤拷锟叫癸拷医学锟斤拷坛锟斤拷锟斤拷
锟斤拷锟斤拷锟斤拷锟斤拷医学协锟斤拷锟节匡拷锟斤拷锟斤拷JAMA锟斤拷锟斤拷301(7):745-752. 锟斤拷Scott A. Waldman锟斤拷David S. Weinberg锟斤拷
锟斤拷锟斤拷锟侥讹拷锟斤拷英锟侥ｏ拷
