锟斤拷锟秸ｏ拷锟叫匡拷院锟较猴拷药锟斤拷锟斤拷药锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟叫撅拷员锟斤拷锟斤拷锟斤拷锟斤拷药锟斤发锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷模锟紻DDC锟斤拷锟斤拷锟斤拷锟斤拷锟叫撅拷员锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟绞匡拷锟斤拷锟斤拷锟结锟斤拷锟斤拷锟斤拷锟斤拷锟叫撅拷锟斤拷锟街ｏ拷锟斤拷然Ser139锟斤拷Phe140锟斤拷SARS锟斤拷锟斤拷水锟斤拷酶锟斤拷SARS 3CLpro锟斤拷锟斤拷锟桔斤拷锟斤拷锟斤拷锟斤拷诎锟斤拷锟斤拷幔拷锟酵伙拷锟斤拷锟斤拷锟斤拷同锟斤拷酶锟侥聚硷拷状态锟酵伙拷锟皆ｏ拷锟斤拷Ser139突锟斤拷使酶锟皆碉拷锟斤拷锟斤拷式锟斤拷锟节ｏ拷锟斤拷却锟斤拷锟斤拷一锟斤拷锟斤拷酶学锟斤拷锟皆ｏ拷锟斤拷Phen140突锟斤拷使酶锟皆讹拷锟斤拷锟斤拷式锟斤拷锟节ｏ拷却丧失锟斤拷锟皆ｏ拷通锟斤拷锟斤拷锟斤拷峁癸拷锟斤拷锟斤拷锟斤拷锟斤拷锟较低筹拷芯锟斤拷锟�“3CL水锟斤拷酶酶锟斤拷”锟斤拷“锟桔硷拷状态”锟侥癸拷系锟斤拷锟斤拷应锟缴癸拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷一锟节的★拷锟斤拷锟斤拷学锟斤拷锟斤拷Virology, 2009, 388, 324-334锟斤拷锟斤拷志锟较ｏ拷锟斤拷锟斤拷锟斤拷为锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟皆斤拷锟杰★拷
2003锟斤拷全锟斤拷锟斤拷锟斤拷SARS锟节间，锟斤拷锟斤拷锟叫撅拷员锟酵斤拷锟斤拷锟斤拷锟叫撅拷员锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷通锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷投锟诫到“SARS锟斤拷锟斤拷锟斤拷要锟斤拷锟阶癸拷锟斤拷锟叫撅拷”锟叫ｏ拷锟斤拷锟斤拷为止锟斤拷取锟斤拷一系锟叫革拷锟叫硷拷值锟侥成癸拷锟斤拷锟界发锟街诧拷证实SARS锟斤拷锟斤拷N锟斤拷锟斤拷锟斤拷锟斤拷CypA锟斤拷锟斤拷锟斤拷锟斤拷SARS锟斤拷锟斤拷锟斤拷染锟斤拷锟斤拷锟斤拷锟斤拷细锟斤拷锟斤拷一锟斤拷锟斤拷锟斤拷途锟斤拷锟斤拷为SARS锟斤拷锟斤拷锟斤拷染锟斤拷锟斤拷锟斤拷锟斤拷芯锟斤拷峁╋拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟斤拷锟絊ARS 3CLpro G11A突锟斤拷锟斤拷锟节撅拷锟斤拷锟斤拷锟皆碉拷锟斤拷锟斤拷式锟斤拷锟节ｏ拷锟斤拷锟斤拷锟斤拷锟斤拷3CL锟斤拷锟斤拷酶锟斤拷锟斤拷锟斤拷锟斤拷纬锟斤拷锟斤拷榷锟斤拷锟斤拷啤锟�
锟剿次碉拷锟铰凤拷锟街ｏ拷锟斤拷锟斤拷为锟斤拷锟斤拷SARS 3CLpro锟斤拷锟皆和催伙拷锟斤拷锟斤拷锟结供锟斤拷锟斤拷要锟截材ｏ拷锟斤拷锟斤拷为锟斤拷锟斤拷3CLpro为锟叫碉拷目锟絊ARS锟斤拷锟斤拷夭锟斤拷锟斤拷锟揭╋拷锟斤拷锟斤拷锟结供锟斤拷锟铰碉拷锟叫撅拷锟斤拷锟皆★拷锟斤拷锟斤拷源锟斤拷锟叫匡拷院锟较猴拷药锟斤拷锟叫撅拷锟斤拷锟斤拷
