科学家发现广泛性流感抗体
作者：小柯机器人 发布时间：2019/10/25 17:04:48
美国纽约西奈山伊坎医学院Florian Krammer、圣路易斯华盛顿大学Ali H. Ellebedy以及斯克里普斯研究所Ian A. Wilson等研究人员，合作发现针对流感病毒神经氨酸酶活性部位的广泛性保护抗体。相关论文发表于10月25日出版的《科学》杂志。
研究人员报道了从H3N2感染的供体分离的三种人类单克隆抗体，它们广泛地结合多种不同的甲型和乙型流感病毒神经氨酸酶。这些抗体可中和病毒，介导效应子功能，在体内具有广泛的保护作用，并通过直接结合到活性位点来抑制神经氨酸酶活性。这些抗体的结构和功能表征将指导基于神经氨酸酶的通用流感疫苗的开发。
据了解，目前迫切需要更好的针对流感病毒的疫苗，以针对各种菌株、亚型和类型提供更广泛的保护。通过鉴定保护性抗体靶向的新型广泛中和的表位能够帮助这一研究。流感疫苗的开发主要集中在血凝素上，但另一种主要的表面抗原神经氨酸酶又重新成为通用疫苗的潜在靶标。
附：英文原文
Title:Broadly protective human antibodies that target the active site of influenza virus neuraminidase
Author:Daniel Stadlbauer1,2,*, Xueyong Zhu3,*, Meagan McMahon1, Jackson S. Turner4, Teddy J. Wohlbold1,5,6, Aaron J. Schmitz4, Shirin Strohmeier1, Wenli Yu3, Raffael Nachbagauer1, Philip A. Mudd7, Ian A. Wilson3,8,†, Ali H. Ellebedy4,†, Florian Krammer1,
Issue&Volume:2019/10/25
Abstract: Better vaccines against influenza virus are urgently needed to provide broader protection against diverse strains, subtypes, and types. Such efforts are assisted by the identification of novel broadly neutralizing epitopes targeted by protective antibodies. Influenza vaccine development has largely focused on the hemagglutinin, but the other major surface antigen, the neuraminidase, has reemerged as a potential target for universal vaccines. We describe three human monoclonal antibodies isolated from an H3N2-infected donor that bind with exceptional breadth to multiple different influenza A and B virus neuraminidases. These antibodies neutralize the virus, mediate effector functions, are broadly protective in vivo, and inhibit neuraminidase activity by directly binding to the active site. Structural and functional characterization of these antibodies will inform the development of neuraminidase-based universal vaccines against influenza virus.
DOI:10.1126/science.aay0678
期刊信息
Science：《科学》，创刊于1880年。隶属于美国科学促进会，最新IF：41.037