荷兰格罗宁根大学（RUG）Marco Demaria、西班牙巴塞罗那科学技术研究所（BIST）Manuel Serrano以及希腊雅典国立和卡波迪斯安大学Vassilis Gorgoulis团队合作发表文章，展望了细胞衰老。论文发表在10月31日的《细胞》杂志上。

他们提出国际细胞衰老协会（ICSA）达成共识，定义并讨论了衰老的关键细胞和分子特征，并提供了有关如何将其用作生物标记物的建议。他们还提供了一个资源工具SeneQuest（可从http://Senequest.net获得），以便鉴定与衰老相关的基因。

最后，他们提出了一种算法，可以在培养的细胞和体内准确评估和定量衰老。

据介绍，细胞衰老是一种细胞状态，涉及各种生理过程和各种与年龄有关的疾病。近日，靶向治疗衰老以改善老龄化健康水平以及与衰老相关疾病的热度飙升，亦称为senotherapy。因此，准确检测衰老细胞，尤其是体内衰老细胞至关重要。

附：英文原文

Title: Cellular Senescence: Defining a Path Forward

Author: Vassilis Gorgoulis, Peter D. Adams, Andrea Alimonti, Dorothy C. Bennett, Oliver Bischof, Cleo Bishop, Judith Campisi, Manuel Collado, Konstantinos Evangelou, Gerardo Ferbeyre, Jesús Gil, Eiji Hara, Valery Krizhanovsky, Diana Jurk, Andrea B. Maier, Masashi Narita, Laura Niedernhofer, Joo F. Passos, Paul D. Robbins, Clemens A. Schmitt, John Sedivy, Konstantinos Vougas, Thomas von Zglinicki, Daohong Zhou, Manuel Serrano, Marco Demaria

Issue&Volume: 2019/10/31

Abstract: Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellular and molecular features of senescence and offering recommendations on how to use them as biomarkers. We also present a resource tool to facilitate the identification of genes linked with senescence, SeneQuest (available at http://Senequest.net). Lastly, we propose an algorithm to accurately assess and quantify senescence, both in cultured cells and in vivo.

DOI: 10.1016/j.cell.2019.10.005

Source: https://www.cell.com/cell/fulltext/S0092-8674(19)31121-3