美国波士顿大学Laura D. Lewis小组最新研究发现了人体睡眠过程中的电生理，血液动力学和脑脊液振荡耦合。 相关论文发表于11月1日出版的国际学术期刊《科学》。

研究人员使用加速神经影像技术来测量人脑的生理和神经动力学。研究人员发现在非快速眼动睡眠期间出现了振荡的电生理、血液动力学和脑脊液（CSF）的动态变化。 神经慢波之后是血液动力学振荡，而血液动力学振荡又与CSF流量相关。这些结果表明，沉睡的大脑在宏观范围内表现出CSF流动波，并且这些CSF动态与神经和血液动力学节律相互关联。

研究人员表示睡眠对于认知和维持正常的大脑功能至关重要。神经活动中的慢波有助于记忆巩固，而脑脊液清除大脑中的代谢废物。但尚不清楚这两个过程是否相关联。

附：英文原文

Title: Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

Author: Nina E. Fultz, Giorgio Bonmassar, Kawin Setsompop, Robert A. Stickgold, Bruce R. Rosen, Jonathan R. Polimeni, Laura D. Lewis

Issue&Volume: 2019/11/01

Abstract: Sleep is essential for both cognition and maintenance of healthy brain function. Slow waves in neural activity contribute to memory consolidation, whereas cerebrospinal fluid (CSF) clears metabolic waste products from the brain. Whether these two processes are related is not known. We used accelerated neuroimaging to measure physiological and neural dynamics in the human brain. We discovered a coherent pattern of oscillating electrophysiological, hemodynamic, and CSF dynamics that appears during non–rapid eye movement sleep. Neural slow waves are followed by hemodynamic oscillations, which in turn are coupled to CSF flow. These results demonstrate that the sleeping brain exhibits waves of CSF flow on a macroscopic scale, and these CSF dynamics are interlinked with neural and hemodynamic rhythms.

DOI: 10.1126/science.aax5440

Source:https://science.sciencemag.org/content/366/6465/628