美国斯坦福大学医学院Siddhartha Jaiswal和波士顿霍华德·休斯研究所Benjamin L. Ebert合作，发表综述性文章阐述了克隆性造血在人类衰老和疾病中的作用。 相关论文发表在11月1日出版的《科学》杂志上。

随着年龄的增长，人体组织中会积累越来越多的体细胞突变。尽管大多数突变几乎没有发挥功能，但也可能会产生赋予细胞适应性优势的突变。当该过程在造血系统中发生时，可能会造成很大一部分循环的血细胞是来自于同一个单突变的干细胞。 这种被称为“克隆性造血”的情况在老年人口中非常普遍。

研究者讨论了克隆性血细胞生成、其与恶性肿瘤的关系、与衰老的非恶性疾病的联系及其对免疫功能潜在影响的最新进展。探究克隆性造血的功能便于人们了解所有体细胞组织中可能发生的突变和选择过程。

附：英文原文

Title: Clonal hematopoiesis in human aging and disease

Author: Siddhartha Jaiswal, Benjamin L. Ebert

Issue&Volume: 2019/11/01

Abstract: As people age, their tissues accumulate an increasing number of somatic mutations. Although most of these mutations are of little or no functional consequence, a mutation may arise that confers a fitness advantage on a cell. When this process happens in the hematopoietic system, a substantial proportion of circulating blood cells may derive from a single mutated stem cell. This outgrowth, called “clonal hematopoiesis,” is highly prevalent in the elderly population. Here we discuss recent advances in our knowledge of clonal hematopoiesis, its relationship to malignancies, its link to nonmalignant diseases of aging, and its potential impact on immune function. Clonal hematopoiesis provides a glimpse into the process of mutation and selection that likely occurs in all somatic tissues.

DOI: 10.1126/science.aan4673

Source: https://science.sciencemag.org/content/366/6465/eaan4673