美国纽约大学Rahul Satija、Broad研究所Aviv Regev以及英国剑桥大学John C. Marioni等研究人员提出应建立人体通用参考框架。相关论文2019年12月12日发表在《细胞》上。

随着新技术实现细粒度和空间解析的分子谱分析，我们需要新的计算方法，以将来自不同个体同一器官的数据整合到一致的参考中，并在组织学和解剖学规模上构建分子和细胞组织的图谱。研究人员回顾了先前的工作并讨论了建立这样一个共同的坐标框架，组织和器官的基础图所涉及的挑战。研究人员专注于处理个体之间的解剖变异的策略，并强调了对跨越空间分辨率的多个层次尺度的新技术和分析方法的需求。

研究人员表示，了解个体表型异质性的遗传和分子驱动因素对生物学至关重要。

附：英文原文

Title: Toward a Common Coordinate Framework for the Human Body

Author: Jennifer E. Rood, Tim Stuart, Shila Ghazanfar, Tommaso Biancalani, Eyal Fisher, Andrew Butler, Anna Hupalowska, Leslie Gaffney, William Mauck, Gken Eraslan, John C. Marioni, Aviv Regev, Rahul Satija

Issue&Volume: 2019/12/12

Abstract: Understanding the genetic and molecular drivers of phenotypic heterogeneity across individuals is central to biology. As new technologies enable fine-grained and spatially resolved molecular profiling, we need new computational approaches to integrate data from the same organ across different individuals into a consistent reference and to construct maps of molecular and cellular organization at histological and anatomical scales. Here, we review previous efforts and discuss challenges involved in establishing such a common coordinate framework, the underlying map of tissues and organs. We focus on strategies to handle anatomical variation across individuals and highlight the need for new technologies and analytical methods spanning multiple hierarchical scales of spatial resolution.

DOI: 10.1016/j.cell.2019.11.019

Source: https://www.cell.com/cell/fulltext/S0092-8674(19)31275-9