近日，瑞典KTH皇家理工学院Mathias Uhlen等研究人员合作完成了人类血细胞中蛋白质编码基因的全基因组转录组学分析。这一研究成果于2019年12月20日发表在国际学术期刊《科学》上。

研究人员对分类的血液免疫细胞群体中的蛋白质编码基因进行了全基因组转录组分析，以表征不同血细胞类型的各个基因的表达水平。所有数据均作为人类蛋白质图谱的一部分提供在交互式开放式血液图谱中，并与所有主要组织的表达谱整合在一起，以提供所有蛋白质编码基因的空间分类。这允许对人类免疫细胞群体和所有主要人类组织和器官的表达谱进行全基因组探索。

据介绍，在临床和研究环境中，血液都是人类进行分子分析的主要来源。它是许多治疗策略的目标，从而强调需要对构成人血的细胞进行全面的分子图谱分析。

附：英文原文

Title: A genome-wide transcriptomic analysis of protein-coding genes in human blood cells

Author: Mathias Uhlen, Max J. Karlsson, Wen Zhong, Abdellah Tebani, Christian Pou, Jaromir Mikes, Tadepally Lakshmikanth, Bjrn Forsstrm, Fredrik Edfors, Jacob Odeberg, Adil Mardinoglu, Cheng Zhang, Kalle von Feilitzen, Jan Mulder, Evelina Sjstedt, Andreas Hober, Per Oksvold, Martin Zwahlen, Fredrik Ponten, Cecilia Lindskog, sa Sivertsson, Linn Fagerberg, Petter Brodin

Issue&Volume: 2019/12/20

Abstract: Blood is the predominant source for molecular analyses in humans, both in clinical and research settings. It is the target for many therapeutic strategies, emphasizing the need for comprehensive molecular maps of the cells constituting human blood. In this study, we performed a genome-wide transcriptomic analysis of protein-coding genes in sorted blood immune cell populations to characterize the expression levels of each individual gene across the blood cell types. All data are presented in an interactive, open-access Blood Atlas as part of the Human Protein Atlas and are integrated with expression profiles across all major tissues to provide spatial classification of all protein-coding genes. This allows for a genome-wide exploration of the expression profiles across human immune cell populations and all major human tissues and organs.

DOI: 10.1126/science.aax9198

Source: https://science.sciencemag.org/content/366/6472/eaax9198