德国马克斯·普朗克感染生物学研究所Stefan H. E. Kaufmann研究小组的最新工作表明，宿主能够监测铜绿假单胞菌感染期间的群体感应（QS）。相关论文于2019年12月20日发表于国际学术期刊《科学》。

研究人员报道了由烃受体（AhR）在宿主中的调控模式，这主要取决于铜绿假单胞菌定性和定性检测。QS分子与AhR结合并明显调节其活性。这反映在感染了从不同生长阶段收集的铜绿假单胞菌和QS突变体上。研究人员认为通过监视细菌群体，AhR充当感染动态的主要传感器，能够根据感染的状态来协调宿主防御。

据了解，铜绿假单胞菌通过QS快速适应变化的条件，群体感应是一种通信系统，可通过信号分子的产生、释放和检测共同改变其行为。QS分子也可以被宿主感知，尽管对各自的受体和信号传导途径知之甚少。

附：英文原文

Title: Host monitoring of quorum sensing during Pseudomonas aeruginosa infection

Author: Pedro Moura-Alves, Andreas Puyskens, Anne Stinn, Marion Klemm, Ute Guhlich-Bornhof, Anca Dorhoi, Jens Furkert, Annika Kreuchwig, Jonas Protze, Laura Lozza, Gang Pei, Philippe Saikali, Carolina Perdomo, Hans J. Mollenkopf, Robert Hurwitz, Frank Kirschhoefer, Gerald Brenner-Weiss, January Weiner, Hartmut Oschkinat, Michael Kolbe, Gerd Krause, Stefan H. E. Kaufmann

Issue&Volume: 2019/12/20

Abstract: Pseudomonas aeruginosa rapidly adapts to altered conditions by quorum sensing (QS), a communication system that it uses to collectively modify its behavior through the production, release, and detection of signaling molecules. QS molecules can also be sensed by hosts, although the respective receptors and signaling pathways are poorly understood. We describe a pattern of regulation in the host by the aryl hydrocarbon receptor (AhR) that is critically dependent on qualitative and quantitative sensing of P. aeruginosa quorum. QS molecules bind to AhR and distinctly modulate its activity. This is mirrored upon infection with P. aeruginosa collected from diverse growth stages and with QS mutants. We propose that by spying on bacterial quorum, AhR acts as a major sensor of infection dynamics, capable of orchestrating host defense according to the status quo of infection.

DOI: 10.1126/science.aaw1629

Source: https://science.sciencemag.org/content/366/6472/eaaw1629