美国索尔克生物研究所Satchidananda Panda、Ludovic S. Mure等研究人员合作揭示了人类本质性光敏视网膜神经节细胞（ipRGC）的功能多样性。相关论文发表在2019年12月6日出版的《科学》上。

研究人员使用了人体器官供体的制备方法来测量人体ipRGC的光反应。研究人员发现了三种功能性ipRGC亚型，具有不同的敏感性和对光的响应。一种ipRGC亚型的反应似乎取决于外源发色团的供应，并且该反应在人和小鼠视网膜中均保持不变。视杆细胞和视锥细胞还为ipRGC提供了输入；然而，每种亚型都以独特的方式整合了外部视网膜光信号。

据了解，ipRGC是参与图像形成和非图像形成视觉反应细胞的亚群。 尽管已经在啮齿动物中描述了ipRGC的功能亚型和形态亚型，但是在灵长类动物或人的视网膜中尚未鉴定出等同的功能亚型。

附：英文原文

Title: Functional diversity of human intrinsically photosensitive retinal ganglion cells

Author: Ludovic S. Mure, Frans Vinberg, Anne Hanneken, Satchidananda Panda

Issue&Volume: 2019/12/06

Abstract: Intrinsically photosensitive retinal ganglion cells (ipRGCs) are a subset of cells that participate in image-forming and non–image-forming visual responses. Although both functional and morphological subtypes of ipRGCs have been described in rodents, parallel functional subtypes have not been identified in primate or human retinas. In this study, we used a human organ donor preparation method to measure human ipRGCs’ photoresponses. We discovered three functional ipRGC subtypes with distinct sensitivities and responses to light. The response of one ipRGC subtype appeared to depend on exogenous chromophore supply, and this response is conserved in both human and mouse retinas. Rods and cones also provided input to ipRGCs; however, each subtype integrated outer retina light signals in a distinct fashion.

DOI: 10.1126/science.aaz0898

Source:https://science.sciencemag.org/content/366/6470/1251