加州大学伯克利分校Gregory M. Barton研究团队宣布他们的最新研究提出了在体内平衡过程中，Akkermansia muciniphila引起肠道适应性免疫反应，在小鼠中诱导免疫球蛋白G1（IgG1）抗体和抗原特异性T细胞应答。 相关论文发表在2019年6月21日出版的《科学》杂志上。

该研究团队发现Akkermansia muciniphila，一种与宿主代谢和PD-1检查点免疫疗法的全身作用相关的肠道细菌，在小鼠中诱导免疫球蛋白G1（IgG1）抗体和抗原特异性T细胞应答。不同于之前所描述的粘膜反应，T细胞对A. muciniphila的反应仅限于生长期环境下的T滤泡辅助细胞，没有明显的其他辅助T细胞的诱导或向固有层迁移。然而，A. muciniphila特异性反应依赖于环境，并在不同小鼠间存在异质性。这些发现表明，在稳态过程中，环境信号影响T细胞对微生物群的反应，并调节宿主免疫功能。

据了解，肠适应性免疫反应影响宿主健康，但目前只有少数几种肠道细菌能在体内平衡过程中诱导同源的适应性免疫反应。

附：英文原文

Title: Akkermansia muciniphila induces intestinal adaptive immune responses during homeostasis

Author: Eduard Ansaldo, Leianna C. Slayden, Krystal L. Ching, Meghan A. Koch, Natalie K. Wolf, Damian R. Plichta, Eric M. Brown, Daniel B. Graham, Ramnik J. Xavier, James J. Moon, Gregory M. Barton

Issue&Volume: Vol 364, Issue 6446,21 June 2019

Abstract: Intestinal adaptive immune responses influence host health, yet only a few intestinal bacteria species that induce cognate adaptive immune responses during homeostasis have been identified. Here, we show that Akkermansia muciniphila, an intestinal bacterium associated with systemic effects on host metabolism and PD-1 checkpoint immunotherapy, induces immunoglobulin G1 (IgG1) antibodies and antigen-specific T cell responses in mice. Unlike previously characterized mucosal responses, T cell responses to A. muciniphila are limited to T follicular helper cells in a gnotobiotic setting, without appreciable induction of other T helper fates or migration to the lamina propria. However, A. muciniphila–specific responses are context dependent and adopt other fates in conventional mice. These findings suggest that, during homeostasis, contextual signals influence T cell responses to the microbiota and modulate host immune function.

DOI: 10.1126/science.aaw7479

Source:https://science.sciencemag.org/content/364/6446/1179