近日，美国加州大学尔湾分校的Paolo Sassone-Corsi研究组发现，运动的时间决定对肌肉代谢途径和全身能量稳态的影响。相关论文发表在2019年7月2日出版的国际学术期刊《细胞—代谢》上。

利用高通量转录组学和代谢组学方法，研究人员鉴定了在晚上（早期休息期间）或者早上（早期活跃期间）进行运动对于小鼠代谢波动中的不同响应。值得注意的是，糖酵解激活特定地发生在早上运动中。在分子水平上，HIF1α（一个在低氧情况下糖酵解的关键调控因子）能在运动时以时间依赖的方式选择性激活，从而消耗碳水化合物、使用替代性能量物质并适应全身的能耗。这些发现表明，对于锻炼在骨骼肌代谢通路和全身性能量稳态的作用而言，正确选择一天中的时间段是增加这些好处的一个关键因素。

尽管食物摄入的时间对于能量代谢很重要，但目前还不清楚运动对能量代谢的影响是否仅限于特定的时间段。由于昼夜节律调节是控制新陈代谢的关键，因此了解在一天中不同时间进行的运动的影响与生理和体内平衡有关。

附：英文原文

Title: Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis

Author: Shogo Sato, Astrid Linde Basse, Milena Schnke, Siwei Chen, Muntaha Samad, Rhianna C. Laker, Emilie Dalbram, Romain Barrès, Pierre Baldi, Jonas T. Treebak, Juleen R. Zierath, Paolo Sassone-Corsi

Issue&Volume:Jul 02, 2019 Volume 30Issue 1

Abstract: While the timing of food intake is important, it is unclear whether the effects of exercise on energy metabolism are restricted to unique time windows. As circadian regulation is key to controlling metabolism, understanding the impact of exercise performed at different times of the day is relevant for physiology and homeostasis. Using high-throughput transcriptomic and metabolomic approaches, we identify distinct responses of metabolic oscillations that characterize exercise in either the early rest phase or the early active phase in mice. Notably, glycolytic activation is specific to exercise at the active phase. At the molecular level, HIF1α, a central regulator of glycolysis during hypoxia, is selectively activated in a time-dependent manner upon exercise, resulting in carbohydrate exhaustion, usage of alternative energy sources, and adaptation of systemic energy expenditure. Our findings demonstrate that the time of day is a critical factor to amplify the beneficial impact of exercise on both metabolic pathways within skeletal muscle and systemic energy homeostasis.

DOI: https://doi.org/10.1016/j.cmet.2019.03.013

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30183-4