近日，来自韩国科学技术院的Gou Young Koh和Sung-Hong Park研究组合作揭示了颅底淋巴管参与脑脊液引流。相关论文发表在2019年8月1日出版的国际学术期刊《自然》上。

通过可视化脑膜淋巴管（mLV）不同的解剖学定位以及描述其特异化的形态特征，研究人员揭示了颅骨基底侧mLV在引流脑脊液中的重要性，即促进脑脊液的摄入与引流。与背侧的mLV不同，基底mLV具有淋巴管和毛细血管，在小鼠中其位置与蛛网膜下腔临近。研究人员发现基底mLV主要负责脑脊液大分子的清除，而两种mLV的完整性以及脑脊液清除的效率都会随着衰老而受损。因此，这些发现增进了mLV如何参与衰老过程中神经病理生理过程的认知。

最近的研究表明，位于颅骨背侧的脑膜淋巴管(mLV)，参与脑脊液(CSF)的清除，但脑脊液引流的确切路线仍是未知。

附：英文原文

Title: Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

Author: Ji Hoon Ahn, Hyunsoo Cho, Jun-Hee Kim, Shin Heun Kim, Je-Seok Ham, Intae Park, Sang Heon Suh, Seon Pyo Hong, Joo-Hye Song, Young-Kwon Hong, Yong Jeong, Sung-Hong Park, Gou Young Koh

Issue&Volume: Volume 572 Issue 7767

Abstract: Recent work has shown that meningeal lymphatic vessels (mLVs), mainly in the dorsal part of the skull, are involved in the clearance of cerebrospinal fluid (CSF), but the precise route of CSF drainage is still unknown. Here we reveal the importance of mLVs in the basal part of the skull for this process by visualizing their distinct anatomical location and characterizing their specialized morphological features, which facilitate the uptake and drainage of CSF. Unlike dorsal mLVs, basal mLVs have lymphatic valves and capillaries located adjacent to the subarachnoid space in mice. We also show that basal mLVs are hotspots for the clearance of CSF macromolecules and that both mLV integrity and CSF drainage are impaired with ageing. Our findings should increase the understanding of how mLVs contribute to the neuropathophysiological processes that are associated with ageing.

DOI: 10.1038/s41586-019-1419-5

Source:https://www.nature.com/articles/s41586-019-1419-5