人类胎盘没有微生物组，但可能含有潜在的病原体，这一成果由英国国立卫生研究院生物医学研究中心Gordon C. S. Smith和剑桥大学Julian Parkhill研究团队合作取得。该项研究成果发表在2019年8月15日出版的《自然》上。

研究人员试图确定先兆子痫、自发性早产或胎龄小婴儿的分娩是否与人胎盘中细菌DNA的存在相关。研究人员发现没有证据表明绝大多数胎盘样本中存在细菌，包括复杂和不复杂的妊娠。几乎所有信号都与分娩过程中细菌的获得或实验室试剂受细菌DNA污染有关。例外的是无乳链球菌（Streptococcus agalactiae，B组链球菌），在分娩前约5％的样本中检测到非污染信号。研究人员得出结论，胎盘的细菌感染不是不良妊娠结局的常见原因，并且人类胎盘不存在微生物组，但它确实是临产期获得无乳链球菌的潜在位点，而无乳链球菌是新生儿败血症的主要原因。
 

附：英文原文

Title: Human placenta has no microbiome but can contain potential pathogens

Author: Marcus C. de Goffau, Susanne Lager, Ulla Sovio, Francesca Gaccioli, Emma Cook, Sharon J. Peacock, Julian Parkhill, D. Stephen Charnock-Jones, Gordon C. S. Smith

Issue&Volume: Volume 572 Issue 7769

Abstract: We sought to determine whether pre-eclampsia, spontaneous preterm birth or the delivery of infants who are small for gestational age were associated with the presence of bacterial DNA in the human placenta. Here we show that there was no evidence for the presence of bacteria in the large majority of placental samples, from both complicated and uncomplicated pregnancies. Almost all signals were related either to the acquisition of bacteria during labour and delivery, or to contamination of laboratory reagents with bacterial DNA. The exception was Streptococcus agalactiae (group B Streptococcus), for which non-contaminant signals were detected in approximately 5% of samples collected before the onset of labour. We conclude that bacterial infection of the placenta is not a common cause of adverse pregnancy outcome and that the human placenta does not have a microbiome, but it does represent a potential site of perinatal acquisition of S. agalactiae, a major cause of neonatal sepsis.

DOI: 10.1038/s41586-019-1451-5

Source:https://www.nature.com/articles/s41586-019-1451-5