近日，美国哈佛大学医学院Ramnik J. Xavier及其研究团队总结了炎症性肠病的治疗新机遇，即宿主-微生物群关系的内在机制。该综述文章于2019年8月22日发表于国际学术期刊《细胞》。

据了解，目前对炎症性肠病（IBD）发病机制的研究暗示了宿主遗传、宿主免疫、微生物组和环境暴露之间的复杂相互作用。从遗传学和分子发病机制中收集的机制研究数据为粘膜炎症的主要诱因提供了线索，并指导治疗干预的进展。宿主遗传因子，微生物和微生物代谢物之间复杂的相互作用网络控制着肠内稳态，使得相关途径的分类和机制解析具有挑战性。

在本综述中，研究人员讨论了这些二代治疗的挑战、转化的领域以及发展机遇。

附：英文原文

Title: Therapeutic Opportunities in Inflammatory Bowel Disease: Mechanistic Dissection of Host-Microbiome Relationships

Author: Damian R. Plichta, Daniel B. Graham, Sathish Subramanian, Ramnik J. Xavier

Issue&Volume: Volume 178 Issue 5

Abstract: The current understanding of inflammatory bowel disease (IBD) pathogenesis implicates a complex interaction between host genetics, host immunity, microbiome, and environmental exposures. Mechanisms gleaned from genetics and molecular pathogenesis offer clues to the critical triggers of mucosal inflammation and guide the development of therapeutic interventions. A complex network of interactions between host genetic factors, microbes, and microbial metabolites governs intestinal homeostasis, making classification and mechanistic dissection of involved pathways challenging. In this Review, we discuss these challenges, areas of active translation, and opportunities for development of next-generation therapies.

DOI: https://doi.org/10.1016/j.cell.2019.07.045

Source: https://www.cell.com/cell/fulltext/S0092-8674(19)30845-1