美国普林斯顿大学Joshua D. Rabinowitz团队以猪为模型，定量测定了哺乳动物器官之间代谢产物交换。该研究于2019年9月3日发表于国际一流学术期刊《细胞—代谢》上。

研究人员在禁食的猪中比较了动脉血以及来自11个器官引流静脉血中的代谢物浓度。大于90％的代谢物在至少一个器官中显示出动脉与静脉的差异。令人惊讶的是，肝脏和肾脏不仅释放葡萄糖而且还释放氨基酸，这两者主要由肠和胰腺消耗。肝脏和肾脏表现出额外的意外活动：肝脏优先燃烧不饱和脂肪酸而不是更容易导致动脉粥样化的饱和脂肪酸，而肾脏在燃烧循环柠檬酸盐和净氧化乳酸盐为丙酮酸盐方面是独特的，从而有助于体内循环氧化还原平衡。此外，研究人员还观察了超过700种其他组织特异性代谢产物生成或消耗的情况，例如脾脏释放的核苷酸和胰腺释放的TCA中间产物。这些数据构成了有价值资源，并提供了器官间代谢物交换的定量图谱。

研究人员表示，哺乳动物器官通过循环不断交换代谢物，但缺乏对这种循环过程的全身性分析。

附：英文原文

Title: Metabolite Exchange between Mammalian Organs Quantified in Pigs

Author: Joseph H. Gorman, Robert C. Gorman, Joshua D. Rabinowitz, et al

Issue&Volume: Volume 30 Issue 3

Abstract: Mammalian organs continually exchange metabolites via circulation, but systems-level analysis of this shuttling process is lacking. Here, we compared, in fasted pigs, metabolite concentrations in arterial blood versus draining venous blood from 11 organs. Greater than 90% of metabolites showed arterial-venous differences across at least one organ. Surprisingly, the liver and kidneys released not only glucose but also amino acids, both of which were consumed primarily by the intestine and pancreas. The liver and kidneys exhibited additional unexpected activities: liver preferentially burned unsaturated over more atherogenic saturated fatty acids, whereas the kidneys were unique in burning circulating citrate and net oxidizing lactate to pyruvate, thereby contributing to circulating redox homeostasis. Furthermore, we observed more than 700 other cases of tissue-specific metabolite production or consumption, such as release of nucleotides by the spleen and TCA intermediates by pancreas. These data constitute a high-value resource, providing a quantitative atlas of inter-organ metabolite exchange.

DOI: 10.1016/j.cmet.2019.06.002

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30305-5#