韩国庆北科技大学Jong Kyoung Kim以及英国剑桥大学Bon-Kyoung Koo、Benjamin D. Simons团队合作，发现了成年人胃峡部干细胞的特性和动力学。相关论文2019年9月发表在《细胞—干细胞》上。

基于无偏倚的遗传标记和生物物理模型，研究显示，腺体被划分为两个独立的区域，缓慢循环的干细胞区域维持基部；活跃循环的干细胞区域，通过“间断的”中性漂移动力学过程维持坑-峡部-颈部区域。基于Stmn1和Ki67表达的独立谱系示踪证实，快速循环的峡部干细胞（IsthSCs）维持了坑-峡部-颈部区域。最后，单细胞RNA测序(RNA-seq)分析用于定义单个循环IsthSC群体的分子特性和谱系关系。这些结果确定了IsthSCs的特性和功能。

据介绍，胃体上皮是胃肠道最厚的部分并且快速更新换代。目前已有几种用于峡部和基部区域的胃体干细胞的标记物，然而，峡部干细胞(IsthSCs)的特性和不同干细胞群之间的相互作用仍然存在争议。

附：英文原文

Title: Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells

Author: Seungmin Han, Juergen Fink, David J. Jrg, Eunmin Lee, Min Kyu Yum, Lemonia Chatzeli, Sebastian R. Merker, Manon Josserand, Teodora Trendafilova, Amanda Andersson-Rolf, Catherine Dabrowska, Hyunki Kim, Ronald Naumann, Ji-Hyun Lee, Nobuo Sasaki, Richard Lester Mort, Onur Basak, Hans Clevers, Daniel E. Stange, Anna Philpott, Jong Kyoung Kim, Benjamin D. Simons, Bon-Kyoung Koo

Issue&Volume: Volume 25 Issue 3

Abstract: The gastric corpus epithelium is the thickest part of the gastrointestinal tract and is rapidly turned over. Several markers have been proposed for gastric corpus stem cells in both isthmus and base regions. However, the identity of isthmus stem cells (IsthSCs) and the interaction between distinct stem cell populations is still under debate. Here, based on unbiased genetic labeling and biophysical modeling, we show that corpus glands are compartmentalized into two independent zones, with slow-cycling stem cells maintaining the base and actively cycling stem cells maintaining the pit-isthmus-neck region through a process of "punctuated" neutral drift dynamics. Independent lineage tracing based on Stmn1 and Ki67 expression confirmed that rapidly cycling IsthSCs maintain the pit-isthmus-neck region. Finally, single-cell RNA sequencing (RNA-seq) analysis is used to define the molecular identity and lineage relationship of a single, cycling, IsthSC population. These observations define the identity and functional behavior of IsthSCs.

DOI: 10.1016/j.stem.2019.07.008

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(19)30306-6