美国德克萨斯大学西南医学中心Hesham Sadek、Eric N. Olson等研究人员回顾性总结了心脏再生领域的研究进展。2020年1月2日，国际知名学术期刊《细胞—干细胞》发表了这一成果。

研究人员表示，心脏再生是一个相对较新的生物学领域，也是生物医学研究中最活跃和最具争议的领域之一。考虑到心力衰竭的程度和预后，成功的人类心脏再生疗法的潜在影响不可低估。然而，再生过程非常复杂，过早声称心脏再生的成功既引起了人们的兴趣，也引起了争议。整个领域现在正在进行路线校正，并且开始出现更清晰的画面。尽管存在挑战，但发育生物学的基本原理为实现成人心脏再生和修复的最终目标提供了假设驱动的方法框架。

研究人员讨论了该领域的当前状态，并概述了再生人类心肌的潜在途径。

附：英文原文

Title: Toward the Goal of Human Heart Regeneration

Author: Hesham Sadek, Eric N. Olson

Issue&Volume: 2020/01/02

Abstract: Heart regeneration, a relatively new field of biology, is one of the most active andcontroversial areas of biomedical research. The potential impact of successful humanheart regeneration therapeutics cannot be overstated, given the magnitude and prognosisof heart failure. However, the regenerative process is highly complex, and prematureclaims of successful heart regeneration have both fueled interest and created controversy. Thefield as a whole is now in the process of course correction, and a clearer pictureis beginning to emerge. Despite the challenges, fundamental principles in developmentalbiology have provided a framework for hypothesis-driven approaches toward the ultimategoal of adult heart regeneration and repair. In this review, we discuss the currentstate of the field and outline the potential paths forward toward regenerating thehuman myocardium.

DOI: 10.1016/j.stem.2019.12.004

Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(19)30522-3