西班牙巴塞罗那科技研究所Verena Ruprecht、Stefan Wieser等研究人员合作发现，细胞核可测量细胞本体感受的形状变化来控制动态细胞行为。这一研究成果发表在2020年10月16日出版的国际学术期刊《科学》上。

Title: The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior

Author: Valeria Venturini, Fabio Pezzano, Frederic Català Castro, Hanna-Maria Hkkinen, Senda Jiménez-Delgado, Mariona Colomer-Rosell, Monica Marro, Queralt Tolosa-Ramon, Sonia Paz-López, Miguel A. Valverde, Julian Weghuber, Pablo Loza-Alvarez, Michael Krieg, Stefan Wieser, Verena Ruprecht

Issue&Volume: 2020/10/16

Abstract: The physical microenvironment regulates cell behavior during tissue development and homeostasis. How single cells decode information about their geometrical shape under mechanical stress and physical space constraints within tissues remains largely unknown. Here, using a zebrafish model, we show that the nucleus, the biggest cellular organelle, functions as an elastic deformation gauge that enables cells to measure cell shape deformations. Inner nuclear membrane unfolding upon nucleus stretching provides physical information on cellular shape changes and adaptively activates a calcium-dependent mechanotransduction pathway, controlling actomyosin contractility and migration plasticity. Our data support that the nucleus establishes a functional module for cellular proprioception that enables cells to sense shape variations for adapting cellular behavior to their microenvironment.

DOI: 10.1126/science.aba2644

Source: https://science.sciencemag.org/content/370/6514/eaba2644