美国约翰霍普金斯大学Suzanne L. Topalian等研究人员总结了肿瘤免疫治疗中的新辅助检查点阻断研究。2020年1月31日，国际知名学术期刊《科学》发表了这一论文。

Title: Neoadjuvant checkpoint blockade for cancer immunotherapy

Author: Suzanne L. Topalian, Janis M. Taube, Drew M. Pardoll

Issue&Volume: 2020/01/31

Abstract: Cancer immunotherapies that target the programmed cell death 1 (PD-1):programmed death-ligand 1 (PD-L1) immune checkpoint pathway have ushered in the modern oncology era. Drugs that block PD-1 or PD-L1 facilitate endogenous antitumor immunity and, because of their broad activity spectrum, have been regarded as a common denominator for cancer therapy. Nevertheless, many advanced tumors demonstrate de novo or acquired treatment resistance, and ongoing research efforts are focused on improving patient outcomes. Using anti–PD-1 or anti–PD-L1 treatment against earlier stages of cancer is hypothesized to be one such solution. This Review focuses on the development of neoadjuvant (presurgical) immunotherapy in the era of PD-1 pathway blockade, highlighting particular considerations for biological mechanisms, clinical trial design, and pathologic response assessments. Findings from neoadjuvant immunotherapy studies may reveal pathways, mechanisms, and molecules that can be cotargeted in new treatment combinations to increase anti–PD-1 and anti–PD-L1 efficacy.

DOI: 10.1126/science.aax0182

Source: https://science.sciencemag.org/content/367/6477/eaax0182