美国麻省理工学院Matthew G. Vander Heiden等研究人员总结了支链氨基酸代谢在癌症中的新功能。相关论文发表在2020年2月10日出版的《癌细胞》上。

Title: Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer

Author: Sharanya Sivanand, Matthew G. Vander Heiden

Issue&Volume: 2020/02/10

Abstract: Metabolic pathways must be adapted to support cell processes required for transformation and cancer progression. Amino acid metabolism is deregulated in many cancers, with changes in branched-chain amino acid metabolism specifically affecting cancer cell state as well as systemic metabolism in individuals with malignancy. This review highlights key concepts surrounding the current understanding of branched-chain amino acid metabolism and its role in cancer.

DOI: 10.1016/j.ccell.2019.12.011

Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30581-1