2020年2月10日，《癌细胞》发表了美国杰克逊实验室Roel G.W. Verhaak研究组的最新成果，他们对犬类和人类的自发型胶质瘤进行了突变水平的比较研究。

Author: Samirkumar B. Amin, Kevin J. Anderson, C. Elizabeth Boudreau, Emmanuel Martinez-Ledesma, Emre Kocakavuk, Kevin C. Johnson, Floris P. Barthel, Frederick S. Varn, Cynthia Kassab, Xiaoyang Ling, Hoon Kim, Mary Barter, Ching C. Lau, Chew Yee Ngan, Margaret Chapman, Jennifer W. Koehler, James P. Long, Andrew D. Miller, C. Ryan Miller, Brian F. Porter, Daniel R. Rissi, Christina Mazcko, Amy K. LeBlanc, Peter J. Dickinson, Rebecca A. Packer, Amanda R. Taylor, John H. Rossmeisl, Kevin D. Woolard, Amy B. Heimberger, Jonathan M. Levine, Roel G.W. Verhaak

Issue&Volume: 2020/02/10

Abstract: Sporadic gliomas in companion dogs provide a window on the interaction between tumorigenicmechanisms and host environment. We compared the molecular profiles of canine gliomaswith those of human pediatric and adult gliomas to characterize evolutionarily conservedmammalian mutational processes in gliomagenesis. Employing whole-genome, exome, transcriptome,and methylation sequencing of 83 canine gliomas, we found alterations shared betweencanine and human gliomas such as the receptor tyrosine kinases, TP53 and cell-cycle pathways, and IDH1 R132. Canine gliomas showed high similarity with human pediatric gliomas per robustaneuploidy, mutational rates, relative timing of mutations, and DNA-methylation patterns.Our cross-species comparative genomic analysis provides unique insights into gliomaetiology and the chronology of glioma-causing somatic alterations.

DOI: 10.1016/j.ccell.2020.01.004

Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30043-X