上海交通大学瑞金医院赵维莅、陈赛娟以及黄金艳课题组合作取得一项新成果。他们揭示了自然杀伤T细胞淋巴瘤（NKTCL）的基因组和转录组学表征。相关论文于2020年3月16日发表在《癌细胞》杂志上。

NKTCL是非霍奇金淋巴瘤的侵袭性和异质性实体，与EBV感染密切相关。

为了根据基因组结构改变和爱泼斯坦-巴尔病毒（EBV）序列鉴定NKTCL的分子亚型，研究人员对128例新诊断的NKTCL组织活检样本进行了多组学研究，并定义了三种突出的亚型，它们在起源细、EBV基因表达、转录特征，以及对基于天冬酰胺酶的治疗方案和靶向治疗应答都不相同。

这一新研究确定了EBV相关发病机理的分子网络，并提出了NKTCL的潜在临床治疗策略。

附：英文原文

Title: Genomic and Transcriptomic Characterization of Natural Killer T Cell Lymphoma

Author: Jie Xiong, Bo-Wen Cui, Nan Wang, Yu-Ting Dai, Hao Zhang, Chao-Fu Wang, Hui-Juan Zhong, Shu Cheng, Bin-Shen Ou-Yang, Yu Hu, Xi Zhang, Bin Xu, Wen-Bin Qian, Rong Tao, Feng Yan, Jian-Da Hu, Ming Hou, Xue-Jun Ma, Xin Wang, Yuan-Hua Liu, Zun-Min Zhu, Xiao-Bin Huang, Li Liu, Chong-Yang Wu, Li Huang, Yun-Feng Shen, Rui-Bin Huang, Jing-Yan Xu, Chun Wang, De-Pei Wu, Li Yu, Jian-Feng Li, Peng-Peng Xu, Li Wang, Jin-Yan Huang, Sai-Juan Chen, Wei-Li Zhao

Issue&Volume: 2020/03/16

Abstract: Natural killer/T cell lymphoma (NKTCL) is an aggressive and heterogeneous entity ofnon-Hodgkin lymphoma, strongly associated with Epstein-Barr virus (EBV) infection.To identify molecular subtypes of NKTCL based on genomic structural alterations andEBV sequences, we performed multi-omics study on 128 biopsy samples of newly diagnosedNKTCL and defined three prominent subtypes, which differ significantly in cell oforigin, EBV gene expression, transcriptional signatures, and responses to asparaginase-basedregimens and targeted therapy. Our findings thus identify molecular networks of EBV-associatedpathogenesis and suggest potential clinical strategies on NKTCL.

DOI: 10.1016/j.ccell.2020.02.005

Source: https://www.cell.com/cancer-cell/fulltext/S1535-6108(20)30094-5