研究人员发现，在小鼠和人类中，通过运动所经历的局部损伤会激活一个不依赖于卫星细胞的肌纤维自我修复机制。小鼠肌肉损伤触发了一个涉及钙、Cdc42和磷酸激酶C的信号级联，通过微管和dynein将肌核吸引到受损部位。这些核的移动加速了肌纤维的修复，并在局部传递mRNA来进行细胞重建。肌纤维自我修复是一种细胞自主的保护机制，代表了理解健康和疾病中肌肉结构恢复的另一种模式。
据悉，骨骼肌的再生是一个高度同步的过程，需要肌肉干细胞（卫星细胞）。
附：英文原文
Title: Muscle repair after physiological damage relies on nuclear migration for cellular reconstruction
Author: William Roman, Helena Pinheiro, Mafalda R. Pimentel, Jessica Segalés, Luis M. Oliveira, Esther García-Domínguez, Mari Carmen Gómez-Cabrera, Antonio L. Serrano, Edgar R. Gomes, Pura Muoz-Cánoves
Issue&Volume: 2021-10-15
Abstract: Regeneration of skeletal muscle is a highly synchronized process that requires muscle stem cells (satellite cells). We found that localized injuries, as experienced through exercise, activate a myofiber self-repair mechanism that is independent of satellite cells in mice and humans. Mouse muscle injury triggers a signaling cascade involving calcium, Cdc42, and phosphokinase C that attracts myonuclei to the damaged site via microtubules and dynein. These nuclear movements accelerate sarcomere repair and locally deliver messenger RNA (mRNA) for cellular reconstruction. Myofiber self-repair is a cell-autonomous protective mechanism and represents an alternative model for understanding the restoration of muscle architecture in health and disease.
DOI: abe5620
Source: https://www.science.org/doi/10.1126/science.abe5620