研究人员报道了脑脉络丛中的血管屏障（PVB），它通过细菌衍生的脂多糖对肠道炎症作出反应而被调节。炎症反应诱导PVB在肠道血管屏障开放后，通过上调Wnt/β-catenin信号通路而关闭，使其不能被大分子物质所接触。在一个遗传驱动的脉络丛内皮细胞封闭的模型中，研究人员观察到短期记忆和焦虑样行为的缺陷，表明PVB封闭可能与精神缺陷有关联。因此，与炎症性肠病有关的精神症状可能是肠道-脑血管轴失调的结果。
据介绍，高达40%的炎症性肠病患者会出现社会心理障碍。研究人员以前发现了一个肠道血管屏障，控制着细菌从肠道向肝脏的传播。
附：英文原文
Title: Identification of a choroid plexus vascular barrier closing during intestinal inflammation
Author: Sara Carloni, Alice Bertocchi, Sara Mancinelli, Martina Bellini, Marco Erreni, Antonella Borreca, Daniele Braga, Silvia Giugliano, Alessandro M. Mozzarelli, Daria Manganaro, Daniel Fernandez Perez, Federico Colombo, Antonio Di Sabatino, Diego Pasini, Giuseppe Penna, Michela Matteoli, Simona Lodato, Maria Rescigno
Issue&Volume: 2021-10-22
Abstract: Up to 40% of patients with inflammatory bowel disease present with psychosocial disturbances. We previously identified a gut vascular barrier that controls the dissemination of bacteria from the intestine to the liver. Here, we describe a vascular barrier in the brain choroid plexus (PVB) that is modulated in response to intestinal inflammation through bacteria-derived lipopolysaccharide. The inflammatory response induces PVB closure after gut vascular barrier opening by the up-regulation of the wingless-type, catenin-beta 1 (Wnt/β-catenin) signaling pathway, rendering it inaccessible to large molecules. In a model of genetically driven closure of choroid plexus endothelial cells, we observed a deficit in short-term memory and anxiety-like behavior, suggesting that PVB closure may correlate with mental deficits. Inflammatory bowel disease–related mental symptoms may thus be the consequence of a deregulated gut–brain vascular axis.
DOI: abc6108
Source: https://www.science.org/doi/10.1126/science.abc6108