法国索邦大学Alain Chédotal和Filippo Del Bene团队合作取得一项新突破。他们揭示非远脊骨鱼中存在双侧视觉投影，并且早于四足动物出现。2021年4月9日出版的《科学》杂志发表了这项成果。

他们显示非远洋鱼类中存在双侧视觉投影，并且同侧投影的出现与陆地过渡或掠食行为无关。他们还报告说，指定视觉系统侧向性的发育程序在鱼类和哺乳动物之间有所不同，因为Zic2转录因子（指定四足动物中的同侧视网膜神经节细胞）似乎不存在于鱼类神经节细胞中。但是，人ZIC2在斑马鱼中过表达诱导同侧视觉投射。因此，双侧视觉的出现可能早于四足动物中双目视觉投影的存在。

据介绍，在大多数脊椎动物中，照相机式眼睛包含视网膜神经节细胞神经元，这些神经节细胞神经元投射到大脑两侧的视觉中心。 然而，在鱼类中，神经节细胞仅被神经支配于对侧，这表明在四足动物中出现了双侧视觉投射。

附：英文原文

Title: Bilateral visual projections exist in non-teleost bony fish and predate the emergence of tetrapods

Author: Robin J. Vigouroux, Karine Duroure, Juliette Vougny, Shahad Albadri, Peter Kozulin, Eloisa Herrera, Kim Nguyen-Ba-Charvet, Ingo Braasch, Rodrigo Suárez, Filippo Del Bene, Alain Chédotal

Issue&Volume: 2021/04/09

Abstract: In most vertebrates, camera-style eyes contain retinal ganglion cell neurons that project to visual centers on both sides of the brain. However, in fish, ganglion cells were thought to innervate only the contralateral side, suggesting that bilateral visual projections appeared in tetrapods. Here we show that bilateral visual projections exist in non-teleost fishes and that the appearance of ipsilateral projections does not correlate with terrestrial transition or predatory behavior. We also report that the developmental program that specifies visual system laterality differs between fishes and mammals, as the Zic2 transcription factor, which specifies ipsilateral retinal ganglion cells in tetrapods, appears to be absent from fish ganglion cells. However, overexpression of human ZIC2 induces ipsilateral visual projections in zebrafish. Therefore, the existence of bilateral visual projections likely preceded the emergence of binocular vision in tetrapods.

DOI: 10.1126/science.abe7790

Source: https://science.sciencemag.org/content/372/6538/150