美国斯坦福大学骆利群研究组发现，相互排斥指引并行海马网络的精确组装。相关论文于2021年6月4日发表于国际学术期刊《科学》。

研究人员表明，在小鼠中，细胞表面分子teneurin-3（Ten3）和latrophilin-2（Lphn2）的互补表达分别在中间和横向海马网络中指导在两个网络中的CA1到次要连接的精确组装。在内侧网络中，表达Ten3（Ten3+）的CA1轴突被靶衍生的LPHN2排斥，这揭示了LPHN2和TEN3介导的异嗜性排斥和TEN3介导的同嗜性吸引，从而控制CA1轴突的精确靶选择。

在横向网络中，表达Lphn2（Lphn2+）CA1轴突通过从Ten3+靶标被排斥而局限于Lphn2+靶标。这些研究结果表明，并行海马网络的组装遵循“Ten3→Ten3，Lphn2→Lphn2”规则，这是通过相互排斥来指导的。

据了解，哺乳动物内侧和横向海马网络优先处理空间和对象相关信息。然而，在发育期间，这种平行网络组装的机制仍然很大程度上是未知的。

附：英文原文

Title: Reciprocal repulsions instruct the precise assembly of parallel hippocampal networks

Author: Daniel T. Pederick, Jan H. Lui, Ellen C. Gingrich, Chuanyun Xu, Mark J. Wagner, Yuanyuan Liu, Zhigang He, Stephen R. Quake, Liqun Luo

Issue&Volume: 2021/06/04

Abstract: Mammalian medial and lateral hippocampal networks preferentially process spatial- and object-related information, respectively. However, the mechanisms underlying the assembly of such parallel networks during development remain largely unknown. Our study shows that, in mice, complementary expression of cell surface molecules teneurin-3 (Ten3) and latrophilin-2 (Lphn2) in the medial and lateral hippocampal networks, respectively, guides the precise assembly of CA1-to-subiculum connections in both networks. In the medial network, Ten3-expressing (Ten3+) CA1 axons are repelled by target-derived Lphn2, revealing that Lphn2- and Ten3-mediated heterophilic repulsion and Ten3-mediated homophilic attraction cooperate to control precise target selection of CA1 axons. In the lateral network, Lphn2-expressing (Lphn2+) CA1 axons are confined to Lphn2+ targets via repulsion from Ten3+ targets. Our findings demonstrate that assembly of parallel hippocampal networks follows a “Ten3→Ten3, Lphn2→Lphn2” rule instructed by reciprocal repulsions.

DOI: 10.1126/science.abg1774

Source: https://science.sciencemag.org/content/372/6546/1068