以色列耶路撒冷希伯来大学E. Keshet研究组取得一项新成果。经过不懈努力，他们的研究表明增强与年龄相关VEGF信号促进健康衰老并延长寿命。这一研究成果于2021年7月30日发表在国际学术期刊《科学》上。

研究人员在老年小鼠中发现，由诱饵受体表达增加产生的血管内皮生长因子 (VEGF) 信号不足可能会导致多个器官系统的生理衰老。增加 VEGF信号可以防止与年龄相关的毛细血管损失，改善器官灌注和功能，并延长寿命。健康衰老可由正常的新陈代谢和身体构成以及与衰老相关病理的改善来表征，衰老相关疾病包括肝脂肪变性、肌肉减少症、骨质疏松症、“炎症”（与年龄相关的多器官慢性炎症）和肿瘤负荷增加。

这些结果表明VEGF信号传导不足会影响小鼠的器官衰老，并且调节该途径可能会延长哺乳动物的寿命并改善整体健康状况。

据介绍，衰老是血管疾病的既定危险因素，但血管衰老本身可能会导致器官功能的逐渐恶化。

附：英文原文

Title: Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span

Author: M. Grunewald, S. Kumar, H. Sharife, E. Volinsky, A. Gileles-Hillel, T. Licht, A. Permyakova, L. Hinden, S. Azar, Y. Friedmann, P. Kupetz, R. Tzuberi, A. Anisimov, K. Alitalo, M. Horwitz, S. Leebhoff, O. Z. Khoma, R. Hlushchuk, V. Djonov, R. Abramovitch, J. Tam, E. Keshet

Issue&Volume: 2021/07/30

Abstract: Aging is an established risk factor for vascular diseases, but vascular aging itself may contribute to the progressive deterioration of organ function. Here, we show in aged mice that vascular endothelial growth factor (VEGF) signaling insufficiency, which is caused by increased production of decoy receptors, may drive physiological aging across multiple organ systems. Increasing VEGF signaling prevented age-associated capillary loss, improved organ perfusion and function, and extended life span. Healthier aging was evidenced by favorable metabolism and body composition and amelioration of aging-associated pathologies including hepatic steatosis, sarcopenia, osteoporosis, “inflammaging” (age-related multiorgan chronic inflammation), and increased tumor burden. These results indicate that VEGF signaling insufficiency affects organ aging in mice and suggest that modulating this pathway may result in increased mammalian life span and improved overall health.

DOI: 10.1126/science.abc8479

Source: https://science.sciencemag.org/content/373/6554/eabc8479