澳大利亚墨尔本大学Jose A. Villadangos、Justine D. Mintern等研究人员合作发现，边缘区B细胞通过胞啃作用获得树突状细胞功能。相关论文于2022年2月11日发表在《科学》杂志上。

研究人员表示，边缘区（MZ）B细胞产生广谱抗体，保护生命早期免受感染。在某些情况下，抗体的产生需要MZ B细胞向T细胞展示与主要组织相容性复合体II类（MHC II）分子结合的病原体抗原。

研究人员描述了从传统树突状细胞（cDC）中获取这些分子的胞啃过程。补体成分3（C3）与cDC上的鼠和人类MHC II结合。MZ B细胞用补体受体2（CR2）识别C3，并胞啃MHC II-C3复合物，后者在其细胞表面暴露出来。泛素连接酶MARCH1限制了显示在cDC上MHC II-C3复合物的数量，从而防止它们通过过度的胞啃作用被消除。因此，MHC II对C3的捕获使cDC的类似特性转移到MZ B细胞。

附：英文原文

Title: Marginal zone B cells acquire dendritic cell functions by trogocytosis

Author: Patrick Schriek, Alan C. Ching, Nagaraj S. Moily, Jessica Moffat, Lynette Beattie, Thiago M. Steiner, Laine M. Hosking, Joshua M. Thurman, V. Michael Holers, Satoshi Ishido, Mireille H. Lahoud, Irina Caminschi, William R. Heath, Justine D. Mintern, Jose A. Villadangos

Issue&Volume: 2022-02-11

Abstract: Marginal zone (MZ) B cells produce broad-spectrum antibodies that protect against infection early in life. In some instances, antibody production requires MZ B cells to display pathogen antigens bound to major histocompatibility complex class II (MHC II) molecules to T cells. We describe the trogocytic acquisition of these molecules from conventional dendritic cells (cDCs). Complement component 3 (C3) binds to murine and human MHC II on cDCs. MZ B cells recognize C3 with complement receptor 2 (CR2) and trogocytose the MHC II–C3 complexes, which become exposed on their cell surface. The ubiquitin ligase MARCH1 limits the number of MHC II–C3 complexes displayed on cDCs to prevent their elimination through excessive trogocytosis. Capture of C3 by MHC II thus enables the transfer of cDC-like properties to MZ B cells.

DOI: abf7470

Source: https://www.science.org/doi/10.1126/science.abf7470