美国西北大学John A. Rogers、Igor R. Efimov和Rishi K. Arora研究组合作建立了一种用于自主电疗的无线、身体集成设备的瞬态闭环网络。相关论文于2022年5月27日发表在《科学》杂志上。
他们提出了一个瞬态闭环系统，它将皮肤集成设备的时间同步无线网络与先进的生物可吸收起搏器相结合，以控制心律、跟踪心肺状态、提供多触觉反馈，并以最小的患者负荷实现瞬态操作。结果提供了一系列自主的、频率自适应的心脏起搏能力，如大鼠、犬和人类心脏研究中所证明的那样。这项工作为使用无线连接的身体集成生物电子设备的闭环临时电疗建立了一个工程框架。
据了解，临时术后心脏起搏需要带有经皮导线和外部有线电源和控制系统的设备。该硬件引入了感染风险、患者活动受限以及手术提取程序的要求。生物可吸收起搏器减少了其中一些缺点，但它们需要与外部有线系统和辅助控制机制配对。
附：英文原文
Title: A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy
Author: Yeon Sik Choi, Hyoyoung Jeong, Rose T. Yin, Raudel Avila, Anna Pfenniger, Jaeyoung Yoo, Jong Yoon Lee, Andreas Tzavelis, Young Joong Lee, Sheena W. Chen, Helen S. Knight, Seungyeob Kim, Hak-Young Ahn, Grace Wickerson, Abraham Vázquez-Guardado, Elizabeth Higbee-Dempsey, Bender A. Russo, Michael A. Napolitano, Timothy J. Holleran, Leen Abdul Razzak, Alana N. Miniovich, Geumbee Lee, Beth Geist, Brandon Kim, Shuling Han, Jaclyn A. Brennan, Kedar Aras, Sung Soo Kwak, Joohee Kim, Emily Alexandria Waters, Xiangxing Yang, Amy Burrell, Keum San Chun, Claire Liu, Changsheng Wu, Alina Y. Rwei, Alisha N. Spann, Anthony Banks, David Johnson, Zheng Jenny Zhang, Chad R. Haney, Sung Hun Jin, Alan Varteres Sahakian, Yonggang Huang, Gregory D. Trachiotis, Bradley P. Knight, Rishi K. Arora, Igor R. Efimov, John A. Rogers
Issue&Volume: 2022-05-27
Abstract: Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices.
DOI: abm1703
Source: https://www.science.org/doi/10.1126/science.abm1703