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树突状轴突的起源使锥体神经元通过周身抑制进行信息门控
作者:小柯机器人 发布时间:2022/9/25 21:07:20

德国海德堡大学Martin Both课题组发现,树突状轴突的起源使锥体神经元通过周身抑制进行信息门控。2022年9月23日出版的《科学》杂志发表了这项成果。

研究人员报告了海马锥体细胞被选择性地招募为模式化的网络活动。在清醒小鼠的波纹振荡中,轴突起源于基底树突而非躯干的细胞更有可能出现脉冲。体外的高分辨率记录和计算机建模表明,这些脉冲是由突触输入到携带轴突的树突引起的,因此可以逃避周围的抑制。具有体细胞轴突的锥体细胞可以通过阻断其体细胞抑制在波纹振荡期间被激活。因此,神经元被招募到活动集合体中是由轴突的形态特征决定的。

据了解,神经元网络中的信息处理涉及招募选定的神经元进入协调的时空活动模式。这种稀疏的激活是由广泛的突触抑制与神经元特异性突触兴奋共同作用的结果。

附:英文原文

Title: Dendritic axon origin enables information gating by perisomatic inhibition in pyramidal neurons

Author: Alexander Hodapp, Martin E. Kaiser, Christian Thome, Lingjun Ding, Andrei Rozov, Matthias Klumpp, Nikolas Stevens, Moritz Stingl, Tina Sackmann, Nadja Lehmann, Andreas Draguhn, Andrea Burgalossi, Maren Engelhardt, Martin Both

Issue&Volume: 2022-09-23

Abstract: Information processing in neuronal networks involves the recruitment of selected neurons into coordinated spatiotemporal activity patterns. This sparse activation results from widespread synaptic inhibition in conjunction with neuron-specific synaptic excitation. We report the selective recruitment of hippocampal pyramidal cells into patterned network activity. During ripple oscillations in awake mice, spiking is much more likely in cells in which the axon originates from a basal dendrite rather than from the soma. High-resolution recordings in vitro and computer modeling indicate that these spikes are elicited by synaptic input to the axon-carrying dendrite and thus escape perisomatic inhibition. Pyramidal cells with somatic axon origin can be activated during ripple oscillations by blocking their somatic inhibition. The recruitment of neurons into active ensembles is thus determined by axonal morphological features.

DOI: abj1861

Source: https://www.science.org/doi/10.1126/science.abj1861

 

期刊信息
Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037