以色列魏茨曼科学研究所Ravid Straussman、美国加州大学圣迭戈分校Rob Knight等研究人员合作发现，泛癌症分析揭示癌症类型特有的真菌生态学和细菌组的相互作用。相关论文于2022年9月29日发表于国际学术期刊《细胞》。
研究人员全面地描述了四个独立队列中35种癌症类型的17401个病人组织、血液和血浆样本中的癌症真菌生物组的特征。研究人员报告了在许多主要的人类癌症中真菌DNA和细胞的低丰度，即使考虑到技术背景，不同类型的癌症的群落组成也有差异。组织微阵列的真菌组织学染色支持瘤内存在，并经常与癌细胞和巨噬细胞在空间上有联系。将瘤内真菌群落与相匹配的细菌组和免疫组进行比较，研究人员发现了共同存在的双域生态，通常具有放任性而非竞争性的微环境和不同的免疫反应。临床重点评估表明，组织和血浆霉菌生物组具有预后和诊断能力，甚至在I期癌症中也是如此，并且与细菌组具有协同预测性能。
据了解，几个世纪以来，人们一直在探索癌症与微生物的关系，但与癌症有关的真菌却很少被研究。
附：英文原文
Title: Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions
Author: Lian Narunsky-Haziza, Gregory D. Sepich-Poore, Ilana Livyatan, Omer Asraf, Cameron Martino, Deborah Nejman, Nancy Gavert, Jason E. Stajich, Guy Amit, Antonio González, Stephen Wandro, Gili Perry, Ruthie Ariel, Arnon Meltser, Justin P. Shaffer, Qiyun Zhu, Nora Balint-Lahat, Iris Barshack, Maya Dadiani, Einav N. Gal-Yam, Sandip Pravin Patel, Amir Bashan, Austin D. Swafford, Yitzhak Pilpel, Rob Knight, Ravid Straussman
Issue&Volume: 2022/09/29
Abstract: Cancer-microbe associations have been explored for centuries, but cancer-associated fungi have rarely been examined. Here, we comprehensively characterize the cancer mycobiome within 17,401 patient tissue, blood, and plasma samples across 35 cancer types in four independent cohorts. We report fungal DNA and cells at low abundances across many major human cancers, with differences in community compositions that differ among cancer types, even when accounting for technical background. Fungal histological staining of tissue microarrays supported intratumoral presence and frequent spatial association with cancer cells and macrophages. Comparing intratumoral fungal communities with matched bacteriomes and immunomes revealed co-occurring bi-domain ecologies, often with permissive, rather than competitive, microenvironments and distinct immune responses. Clinically focused assessments suggested prognostic and diagnostic capacities of the tissue and plasma mycobiomes, even in stage I cancers, and synergistic predictive performance with bacteriomes.
DOI: 10.1016/j.cell.2022.09.005
Source: https://www.cell.com/cell/fulltext/S0092-8674(22)01127-8