瑞士洛桑大学Ping-Chih Ho团队近期取得重要工作进展，他们研究提出了免疫编辑指导肿瘤代谢重编程以支持免疫逃逸。相关研究成果2023年1月3日在线发表于《细胞—代谢》杂志上。

据介绍，免疫编辑在肿瘤发生过程中塑造免疫原性并阻断宿主抗肿瘤反应，然而，目前尚不清楚肿瘤细胞的代谢程序是否可以通过免疫监测来指导。

研究人员报道了早期肿瘤发生中T细胞介导的免疫监测指导肿瘤细胞中c-Myc的上调和代谢重编程。这种以前未被探索的肿瘤和免疫相互作用由非典型干扰素γ（IFNγ）-STAT3信号通路控制，并支持肿瘤免疫逃逸。

总之，这一研究发现，免疫编辑通过在肿瘤细胞和浸润T细胞之间进行代谢拉锯战，形成抑制性肿瘤微环境，指导肿瘤细胞的生物能量程序失调，使它们能够解除T细胞介导的免疫监测。

附：英文原文

Title: Immunoediting instructs tumor metabolic reprogramming to support immune evasion

Author: Chin-Hsien Tsai, Yu-Ming Chuang, Xiaoyun Li, Yi-Ru Yu, Sheue-Fen Tzeng, Shao Thing Teoh, Katherine E. Lindblad, Mario Di Matteo, Wan-Chen Cheng, Pei-Chun Hsueh, Kung-Chi Kao, Hana Imrichova, Likun Duan, Hector Gallart-Ayala, Pei-Wen Hsiao, Massimiliano Mazzone, Julijana Ivanesevic, Xiaojing Liu, Karin E. de Visser, Amaia Lujambio, Sophia Y. Lunt, Susan M. Kaech, Ping-Chih Ho

Issue&Volume: 2023/01/03

Abstract: Immunoediting sculpts immunogenicity and thwarts host anti-tumor responses in tumorcells during tumorigenesis; however, it remains unknown whether metabolic programmingof tumor cells can be guided by immunosurveillance. Here, we report that T cell-mediatedimmunosurveillance in early-stage tumorigenesis instructs c-Myc upregulation and metabolicreprogramming in tumor cells. This previously unexplored tumor-immune interactionis controlled by non-canonical interferon gamma (IFNγ)-STAT3 signaling and supportstumor immune evasion. Our findings uncover that immunoediting instructs deregulatedbioenergetic programs in tumor cells to empower them to disarm the T cell-mediatedimmunosurveillance by imposing metabolic tug-of-war between tumor and infiltratingT cells and forming the suppressive tumor microenvironment.

DOI: 10.1016/j.cmet.2022.12.003

Source: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(22)00540-X