研究人员将基因型-组织表达（GTEx）项目的数据与一种算法相结合，通过整合每名个体中多个组织的时间信息，为914名志愿者分配昼夜节律，用于识别46个组织中的信使RNA（mRNA）节律。节律转录本显示保守的时间关系和紧密的同步在整个身体。mRNA节律在广度上有所不同，涵盖了全身和组织特异性功能，包括代谢途径和系统反应。生物钟结构在不同性别和年龄组中都是保守的。然而，整体的基因表达节律具有高度的性别二态性，在女性中更为明显。随着年龄的增长，节律程序一般会减弱。
据了解，生物钟调节人体生理机能。然而，组织特异性基因表达节律的组织以及它们如何依赖于年龄和性别在人类中还没有定义。
附：英文原文
Title: Sex-dimorphic and age-dependent organization of 24-hour gene expression rhythms in humans
Author: Lorenzo Talamanca, Cédric Gobet, Felix Naef
Issue&Volume: 2023-02-03
Abstract: The circadian clock modulates human physiology. However, the organization of tissue-specific gene expression rhythms and how these depend on age and sex is not defined in humans. We combined data from the Genotype-Tissue Expression (GTEx) project with an algorithm that assigns circadian phases to 914 donors, by integrating temporal information from multiple tissues in each individual, to identify messenger RNA (mRNA) rhythms in 46 tissues. Clock transcripts showed conserved timing relationships and tight synchrony across the body. mRNA rhythms varied in breadth, covering global and tissue-specific functions, including metabolic pathways and systemic responses. The clock structure was conserved across sexes and age groups. However, overall gene expression rhythms were highly sex-dimorphic and more sustained in females. Rhythmic programs generally dampened with age across the body.
DOI: add0846
Source: https://www.science.org/doi/10.1126/science.add0846