俄罗斯科学院Аndrei I. Fischer团队报道了生物活性大分子配体及其与铽离子的发光配合物的设计。相关研究成果发表在2024年1月25日出版的《中国高分子科学杂志》。

研究人员采用自由基共聚法合成了具有中性共聚单体（N-乙烯基吡咯烷酮（VP）、N-甲基-N-乙烯基乙酰胺（MVAA）、N-甲丙烯酰基葡糖胺（MAG））甲基丙烯酰胺基苯甲酸（MABA），和阴离子共聚单体苯乙烯磺酸钠（NaSS）的水溶性共聚物。研究了所制备的共聚物与Tb³⁺离子在水溶液中的相互作用，揭示了共聚单体的化学结构对Tb³⁺与共聚物配合物发光强度的显著影响。

Tb³⁺与含有N-乙烯酰胺单元的共聚物（VP，MVAA）的配合物发光强度，是Tb³⁺和含有MAG的共聚物之间的配合物所观察到的强度的三倍。在含有NaSS的共聚物的情况下，发光强度由Tb³⁺和MABA之间的结合常数的值以及共聚物中MABA单元的含量来控制。所研究的共聚物及其与Tb³⁺的复合物具有低的细胞毒性，和对人类呼吸道合胞病毒的显著抗病毒活性。

附：英文原文

Title: Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions

Author: Тatiana N. Nekrasova, Аndrei I. Fischer, Natalia А. Nesterova, Anatoliy V. Dobrodumov, Anzhelika V. Garshinina, Оlga D. Shuvaeva, Natalya V. Zakharova, Evgenii F. Panarin

Issue&Volume: 2024-01-25

Abstract: Water-soluble copolymers of p-methacrylamidobenzoic acid (MABA) with neutral comonomers (N-vinylpyrrolidone (VP), N-methyl-N-vinylacetamide (MVAA), N-methacryloyl glucosamine (MAG)) and anionic comononer sodium styrene sulfonate (NaSS) were synthesized by radical copolymerization. The interactions between the prepared copolymers and Tb3+ ions in aqueous solutions were studied; the significant influence of chemical structure of a comonomer on luminescence intensity of Tb3+ complexes with the copolymers was revealed. The luminescence intensity of Tb3+ complexes with the copolymers containing N-vinylamide units (VP, MVAA) is three times more intense than that observed for the complexes between Tb3+ and MAG-containing copolymers. In the case of NaSS-containing copolymers, the luminescence intensity is controlled by the values of binding constants between Tb3+ and MABA and the content of MABA units in a copolymer. The studied copolymers and their complexes with Tb3+ have low cytotoxicity and a pronounced antiviral activity against human respiratory syncytial virus.

DOI: 10.1007/s10118-024-3081-0

Source: https://www.cjps.org/en/article/doi/10.1007/s10118-024-3081-0/