在猕猴的高风险-高回报（HH）与低风险-低回报（LL）选择任务训练中，研究人员发现腹侧布罗德曼第6区（6V区）的可逆药理失活会损害决策的风险依赖性。选择性光遗传激活从腹侧被盖区（VTA）到6V腹侧的中前通路会导致更强的HH偏好，而激活从VTA到6V背侧的通路则会导致LL偏好。
最后，计算解码捕捉到了行为偏好的调节。这些研究结果表明，VTA对6V区的输入决定了HH和LL之间的决策平衡。
据介绍，决策总是与一定程度的风险相联系，病态形式的冒险决策表现为赌博障碍。
附：英文原文
Title: Balancing risk-return decisions by manipulating the mesofrontal circuits in primates
Author: Ryo Sasaki, Yasumi Ohta, Hirotaka Onoe, Reona Yamaguchi, Takeshi Miyamoto, Takashi Tokuda, Yuki Tamaki, Kaoru Isa, Jun Takahashi, Kenta Kobayashi, Jun Ohta, Tadashi Isa
Issue&Volume: 2024-01-05
Abstract: Decision-making is always coupled with some level of risk, with more pathological forms of risk-taking decisions manifesting as gambling disorders. In macaque monkeys trained in a high risk–high return (HH) versus low risk–low return (LL) choice task, we found that the reversible pharmacological inactivation of ventral Brodmann area 6 (area 6V) impaired the risk dependency of decision-making. Selective optogenetic activation of the mesofrontal pathway from the ventral tegmental area (VTA) to the ventral aspect of 6V resulted in stronger preference for HH, whereas activation of the pathway from the VTA to the dorsal aspect of 6V led to LL preference. Finally, computational decoding captured the modulations of behavioral preference. Our results suggest that VTA inputs to area 6V determine the decision balance between HH and LL.
DOI: adj6645
Source: https://www.science.org/doi/10.1126/science.adj6645