河北医科大学王升等研究人员合作发现，中央杏仁核GABA能神经元的激活导致小鼠低血压。这一研究成果于2024年11月25日在线发表在国际学术期刊《神经科学通报》上。

研究人员表明，光刺激中央杏仁核（CeA）内侧（CeM）的GABA能神经元（与外侧杏仁核CeL中的神经元不同），会在麻醉小鼠和自由活动小鼠中引发降压反应。此外，激活CeM^GABA能神经元的轴突终末，尤其是投射到孤立束核（NTS）的部分，显著降低血压。

这些CeM^GABA能神经元与NTS神经元形成突触连接，从而通过影响尾侧或头侧腹外侧延髓来调节心血管反应。此外，CeM^GABA能神经元通过CeL接受来自CeL的密集输入。因此，CeM^GABA能神经元的刺激通过CeM-NTS回路引发低血压，为情绪和行为相关的心血管反应提供了更深入的见解。

据悉，CeA是情绪、行为和自主功能的重要调节者，包括心血管反应。尽管其重要性不言而喻，但CeA调节血压的具体电路仍然未得到充分探索。

附：英文原文

Title: Activation of Centromedial Amygdala GABAergic Neurons Produces Hypotension in Mice

Author: Wang, Xiaoyi, Yue, Ziteng, Shi, Luo, He, Wei, Shao, Liuqi, Liu, Yuhang, Zhang, Jinye, Bi, Shangyu, Deng, Tianjiao, Yuan, Fang, Wang, Sheng

Issue&Volume: 2024-11-25

Abstract: The central amygdala (CeA) is a crucial modulator of emotional, behavioral, and autonomic functions, including cardiovascular responses. Despite its importance, the specific circuit by which the CeA modulates blood pressure remains insufficiently explored. Our investigations demonstrate that photostimulation of GABAergic neurons in the centromedial amygdala (CeMGABA), as opposed to those in the centrolateral amygdala (CeL), produces a depressor response in both anesthetized and freely-moving mice. In addition, activation of CeMGABA axonal terminals projecting to the nucleus tractus solitarius (NTS) significantly reduces blood pressure. These CeMGABA neurons form synaptic connections with NTS neurons, allowing for the modulation of cardiovascular responses by influencing the caudal or rostral ventrolateral medulla. Furthermore, CeMGABA neurons targeting the NTS receive dense inputs from the CeL. Consequently, stimulation of CeMGABA neurons elicits hypotension through the CeM-NTS circuit, offering deeper insights into the cardiovascular responses associated with emotions and behaviors.

DOI: 10.1007/s12264-024-01317-9

Source: https://link.springer.com/article/10.1007/s12264-024-01317-9