美国洛克菲勒大学曹俊越团队取得重要工作进展。他们研究绘制了哺乳动物衰老过程中细胞种群动态的全景图谱。相关研究成果
为了阐明衰老相关的细胞群体动态，研究人员提出了PanSci，这是一个单细胞转录组图谱，分析了623个不同生命阶段、性别和基因型的小鼠组织中的2000多万个细胞。
这个全面的数据集揭示了3000多种独特的细胞状态和200多种与衰老相关的细胞群。这一全面数据分析揭示了生命进程中细胞动力学的器官、谱系和性别特异性变化。
此外，研究人员还发现了与衰老相关的免疫细胞群中的系统性和器官特异性改变。研究人员进一步探讨了免疫系统对衰老的调节作用，并确定了淋巴细胞依赖性的特定年龄相关细胞群扩增。
总之，这一 “细胞组学”策略增强了对细胞衰老的理解，并为探索衰老和衰老相关疾病中复杂的细胞调控网络奠定了基础。
附：英文原文
Title: A panoramic view of cell population dynamics in mammalian aging
Author: Zehao Zhang, Chloe Schaefer, Weirong Jiang, Ziyu Lu, Jasper Lee, Andras Sziraki, Abdulraouf Abdulraouf, Brittney Wick, Maximilian Haeussler, Zhuoyan Li, Gesmira Molla, Rahul Satija, Wei Zhou, Junyue Cao
Issue&Volume: 2024-11-28
Abstract: To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, sexes, and genotypes. This comprehensive dataset reveals more than 3,000 unique cellular states and over 200 aging-associated cell populations. Our panoramic analysis uncovered organ-, lineage-, and sex-specific shifts of cellular dynamics during lifespan progression. Moreover, we identify both systematic and organ-specific alterations in immune cell populations associated with aging. We further explored the regulatory roles of the immune system on aging and pinpointed specific age-related cell population expansions that are lymphocyte dependent. Our “cell-omics” strategy enhances comprehension of cellular aging and lays the groundwork for exploring the complex cellular regulatory networks in aging and aging-associated diseases.
DOI: adn3949
Source: https://www.science.org/doi/10.1126/science.adn3949