辽宁师范大学白凤英团队报道了从锰三嗪晶体框架到MnOx@NC——抗坏血酸的仿生双酶活性和标记及其在药物中的应用。相关研究成果发表在2024年12月10日出版的《中国化学》。

抗坏血酸（AA）水平的不平衡会对人类健康构成风险。因此，建立一种准确的检测AA的方法至关重要。

该文中，一种新型的氮掺杂碳复合材料(MnOx@NC)通过煅烧含有H3TTPCA配体的Mn-MOF，制备了具有双酶样活性的AA检测试剂。

有趣的是，导致其氧化酶样活性的O₂不是由溶解氧形成的，而是来自煅烧产生的晶格氧和MnII/MnIII/MnIV转化的协同作用，H₂O₂的存在提供了大量的OH，从而导致其过氧化物酶样活性。

同时，残留的N元素来自H3TTPCA配体，有助于催化过程。因此，开发了一种用于检测AA的双信号传感平台和智能手机辅助识别，并建立了一个比色传感器阵列来区分三种抗氧化剂。

该项工作还表明，在真实药品中检测AA具有相当大的前景。

附：英文原文

Title: From Mn-Triazine Crystalline Framework to MnOx@NC: Biomimetic Double-Enzyme Activity and Labeling of Ascorbic Acid as Well as Application in Pharmaceuticals

Author: Shi-Ping Gai, Chen-Wang, Wen-Na Jiao, Bai-Chong Teng, Yu-Xian Chi, Yu-Fei Wang, Yun-Ling Liu, Li-Xian Sun, Yong-Heng Xing, Feng-Ying Bai

Issue&Volume: 2024-12-10

Abstract: Imbalance in the levels of ascorbic acid (AA) can pose a risk to human health. Therefore, it's essential to establish an accurate method for the detection of AA. In this work, a novel N-doped carbon composite (MnOx@NC) with dual enzyme-like activities to detect AA was prepared by calcination of Mn-MOF containing H3TTPCA ligand. Interestingly, the O2 that leads to its oxidase-like activity was not formed by dissolved oxygen, but came from the synergistic effect of lattice oxygen generated by calcination and the transformation of MnII/MnIII/MnIV, and the presence of H2O2 provided much OH, which caused its peroxidase-like activity. Meanwhile, the residual N element came from H3TTPCA ligand assisted the catalytic process. Accordingly, a dual-signal sensing platform and smartphone-assisted recognition for detection of AA was developed and a colorimetric sensor array was established to distinguish three antioxidants. This work also demonstrates considerable promise for the detection of AA in authentic pharmaceuticals.

DOI: 10.1002/cjoc.202400938

Source: https://onlinelibrary.wiley.com/doi/full/10.1002/cjoc.202400938