研究人员发现，表达高亲和力抗体的浆细胞（PC）前体细胞（prePC）在离开生发中心（GC）后，获得了FC碰碰胡老虎机法典-提高赢钱机率的下注技巧来自T辅助滤泡细胞（Tfh）的帮助，并且其增殖速率高于低亲和力的同类细胞。这些研究结果表明，通过选择的prePC细胞的差异性分裂解释了多样的前体细胞如何发展成一个介导血清亲和力成熟的PC群体。
研究人员表示，疫苗接种后抗体亲和力随时间增加，称为亲和力成熟，这是免疫反应的典型特征。最近的研究表明，产生具有不同亲和力谱的抗体的多样B细胞被选择进入PC途径。然而，亲和力许可选择如何促进PC亲和力成熟仍不清楚。
附：英文原文
Title: Affinity maturation of antibody responses is mediated by differential plasma cell proliferation
Author: Andrew J. MacLean, Lachlan P. Deimel, Pengcheng Zhou, Mohamed A. ElTanbouly, Julia Merkenschlager, Victor Ramos, Gabriela S. Santos, Thomas Hgglf, Christian T. Mayer, Brianna Hernandez, Anna Gazumyan, Michel C. Nussenzweig
Issue&Volume: 2024-12-19
Abstract: Increased antibody affinity over time after vaccination, known as affinity maturation, is a prototypical feature of immune responses. Recent studies have shown that a diverse collection of B cells, producing antibodies with a wide spectrum of different affinities, are selected into the plasma cell (PC) pathway. How affinity-permissive selection enables PC affinity maturation remains unknown. We found that PC precursors (prePC) expressing high affinity antibodies received higher levels of T follicular helper (Tfh)-derived help and divided at higher rates than their lower affinity counterparts once they left the GC. Our findings indicated that differential cell division by selected prePCs accounts for how diverse precursors develop into a PC compartment that mediates serological affinity maturation.
DOI: adr6896
Source: https://www.science.org/doi/10.1126/science.adr6896