复旦大学金国新团队报道了基于异喹啉的三层互锁笼的高效自组装。2024年12月17日，《中国化学》发表了这一成果。

据介绍，三联锁系统代表高度复杂的拓扑结构，由两个机械联锁的笼子缠绕而成。实现这些美学拓扑结构的受控和直接构建仍然是一个持久挑战。

该研究团队采用了一种协调驱动的自组装策略，利用半三明治金属单元和精心设计的异喹啉配体的非共价相互作用，实现了有机金属联锁笼1和2的有效构建。

研究人员通过单晶X射线衍射、电喷雾电离质谱和综合核磁共振测试，验证了所得到的三重联锁体系的形成和结构。独立梯度模型（IGM）更直观地展示了笼型化合物内部的多重堆叠相互作用，而平面度分析则阐明了配体的自适应性及其可调构象。

附：英文原文

Title: Efficient Self-assembly of Isoquinoline-Based Triply Interlocked Cages

Author: Qiu-Shui Mu, Xin-Yu Wang, Xiang Gao, Guo-Xin Jin

Issue&Volume: 2024-12-17

Abstract: Triple interlocked systems represent highly intricate topological structures, formed by entwining two mechanically interlocked cages. Achieving controlled and straightforward construction of these aesthetic topologies continues to pose an enduring challenge. Herein, we employ a coordination-driven self-assembly strategy, capitalizing on non-covalent interactions in conjunction with half-sandwich metal units and meticulously designed isoquinoline-based ligands, to achieve the effective construction of organometallic interlocked cages 1 and 2. The resulting triple interlocked system's formation and architecture were validated by single-crystal X-ray diffraction, electrospray ionization mass spectroscopy, and comprehensive NMR tests. The Independent Gradient Model (IGM) more intuitively demonstrates the multiple stacking interactions within cage compounds, while planarity analysis elucidates the self-adaptability of the ligands and their tunable conformations.

DOI: 10.1002/cjoc.202401089

Source: https://onlinelibrary.wiley.com/doi/full/10.1002/cjoc.202401089