2024年12月3日，《自然—神经科学》杂志在线发表了意大利技术研究院Francesco Papaleo小组的最新成果。该研究显示，负面事件的自我经历通过前额叶皮层CRF机制改变对处于相似状态的他人反应。

据悉，人类自己经历的情绪事件会影响其如何接近和反应他人的情绪。

研究人员观察到，小鼠只有在经历过相同的厌恶事件后，才会表现出对他人压力的不同反应（即偏好或回避）。这些反应在雌性小鼠中依赖于发情周期，在雄性小鼠中则依赖于地位。

值得注意的是，沉默前额叶皮层内促肾上腺皮质激素释放因子（CRF）的表达，会减弱压力自我经历对他人压力反应的影响。体内微内窥镜钙成像显示，前额叶皮层CRF神经元仅在经历过相同负面自我经历后，对他人压力的反应更加激活。

光遗传学操作证实，前额叶皮层CRF神经元的更高激活负责在经历自我压力事件后，从偏好转变为回避他人压力。

这些结果提供了一个神经生物学基础，说明个体的情绪经历如何影响他们，对处于负面情绪状态的他人的接近方式。

附：英文原文

Title: Self-experience of a negative event alters responses to others in similar states through prefrontal cortex CRF mechanisms

Author: Maltese, Federica, Pacinelli, Giada, Monai, Anna, Bernardi, Fabrizio, Capaz, Ana Marta, Niello, Marco, Walle, Roman, de Leon, Noelia, Manag, Francesca, Leroy, Felix, Papaleo, Francesco

Issue&Volume: 2024-12-03

Abstract: Our own experience of emotional events influences how we approach and react to others’ emotions. Here we observe that mice exhibit divergent interindividual responses to others in stress (that is, preference or avoidance) only if they have previously experienced the same aversive event. These responses are estrus dependent in females and dominance dependent in males. Notably, silencing the expression of the corticotropin-releasing factor (CRF) within the medial prefrontal cortex (mPFC) attenuates the impact of stress self-experience on the reaction to others’ stress. In vivo microendoscopic calcium imaging revealed that mPFC CRF neurons are activated more toward others’ stress only following the same negative self-experience. Optogenetic manipulations confirmed that higher activation of mPFC CRF neurons is responsible for the switch from preference to avoidance of others in stress, but only following stress self-experience. These results provide a neurobiological substrate underlying how an individual’s emotional experience influences their approach toward others in a negative emotional state.

DOI: 10.1038/s41593-024-01816-y

Source: https://www.nature.com/articles/s41593-024-01816-y