浙江大学医学院Hong Zhang和Mei Tian共同合作，近期取得重要工作进展。他们研究总结了帕金森病突触功能障碍的正电子发射断层成像技术的研究进展及应用。相关工作成果2024年3月14日在线发表于《神经科学通报》杂志上。

据介绍，帕金森病（PD）是最常见的神经退行性疾病之一，发病机制复杂。由α-突触核蛋白（αSyn）的异常沉积形成的聚集导致多巴胺和非多巴胺系统的突触功能障碍。PD的主要病理表现是多巴胺能神经元的丧失和伴随的非多巴胺能功能的改变。

正电子发射断层扫描（PET）作为一种具有代表性的分子成像技术，能够在细胞和分子水平上实现生物过程的非侵入性可视化、表征和量化。用PET对突触功能进行成像将深入了解PD的潜在机制，并促进临床管理的优化。

研究人员在文中重点讨论了与PD的αSyn病理相关的突触功能障碍，总结了各种相关靶点和放射性药物，并讨论了突触功能障碍PET成像在PD中的应用和前景。

附：英文原文

Title: Positron Emission Tomography Imaging of Synaptic Dysfunction in Parkinson’s Disease

Author: Niu, Jiaqi, Zhong, Yan, Jin, Chentao, Cen, Peili, Wang, Jing, Cui, Chunyi, Xue, Le, Cui, Xingyue, Tian, Mei, Zhang, Hong

Issue&Volume: 2024-03-14

Abstract: Parkinson’s disease (PD) is one of the most common neurodegenerative diseases with a complex pathogenesis. Aggregations formed by abnormal deposition of alpha-synuclein (αSyn) lead to synapse dysfunction of the dopamine and non-dopamine systems. The loss of dopaminergic neurons and concomitant alterations in non-dopaminergic function in PD constitute its primary pathological manifestation. Positron emission tomography (PET), as a representative molecular imaging technique, enables the non-invasive visualization, characterization, and quantification of biological processes at cellular and molecular levels. Imaging synaptic function with PET would provide insights into the mechanisms underlying PD and facilitate the optimization of clinical management. In this review, we focus on the synaptic dysfunction associated with the αSyn pathology of PD, summarize various related targets and radiopharmaceuticals, and discuss applications and perspectives of PET imaging of synaptic dysfunction in PD.

DOI: 10.1007/s12264-024-01188-0

Source: https://link.springer.com/article/10.1007/s12264-024-01188-0