滨州医学院Hongliu Sun等研究人员合作总结凝血酶敏感蛋白-1对癫痫形成的贡献。2024年3月26日，《神经科学通报》杂志在线发表了这项成果。

研究人员表示，癫痫是一种神经网络疾病，由兴奋性和抑制性网络失衡引起的神经元过度兴奋所导致。突触生成异常在过度兴奋网络的形成中起着至关重要的作用。最近的证据证实，主要由星形胶质细胞分泌的凝血酶敏感蛋白-1（TSP-1），是癫痫发生过程中调节突触发生的关键细胞因子。

此外，大量研究报告表明，TSP-1还参与了其他过程，如血管生成、神经炎症和Ca²⁺稳态调节，这些过程与癫痫的发生和发展密切相关。研究人员总结了TSP-1对癫痫发展的潜在贡献。

附：英文原文

Title: The Contributions of Thrombospondin-1 to Epilepsy Formation

Author: Cheng, Yao, Zhai, Yujie, Yuan, Yi, Wang, Qiaoyun, Li, Shucui, Sun, Hongliu

Issue&Volume: 2024-03-26

Abstract: Epilepsy is a neural network disorder caused by uncontrolled neuronal hyperexcitability induced by an imbalance between excitatory and inhibitory networks. Abnormal synaptogenesis plays a vital role in the formation of overexcited networks. Recent evidence has confirmed that thrombospondin-1 (TSP-1), mainly secreted by astrocytes, is a critical cytokine that regulates synaptogenesis during epileptogenesis. Furthermore, numerous studies have reported that TSP-1 is also involved in other processes, such as angiogenesis, neuroinflammation, and regulation of Ca2+ homeostasis, which are closely associated with the occurrence and development of epilepsy. In this review, we summarize the potential contributions of TSP-1 to epilepsy development.

DOI: 10.1007/s12264-024-01194-2

Source: https://link.springer.com/article/10.1007/s12264-024-01194-2