南京大学Xia Gao等研究人员合作发现，Luzp2的删除不会导致小鼠听力损失。该项研究成果发表在2024年4月9日出版的《神经科学通报》上。

为了确定Luzp2在听觉功能中的重要性，研究人员产生了缺乏Luzp2的小鼠。研究结果表明，Luzp2主要在毛细胞（HC）和柱细胞中表达。然而，Luzp2的缺失并没有导致听觉阈值发生任何变化。Luzp2基因敲除小鼠的HC或突触数量和HC纤毛形态没有显示出任何明显的差异。

这是首次研究Luzp2在小鼠听力中的作用，这些研究结果为筛选耳聋基因提供了重要指导。

据悉，耳聋是人类普遍存在的感官障碍，影响着人们生活的方方面面。先天性耳聋病例中有一半是由遗传因素造成的。研究表明，Luzp2在内耳的HC和支持细胞中表达，但其在听觉中的具体作用仍不清楚。

附：英文原文

Title: Deletion of Luzp2 Does Not Cause Hearing Loss in Mice

Author: Cheng, Cheng, Zhu, Guangjie, Wang, Kaijian, Bu, Chuan, Li, Siyu, Qiu, Yue, Lu, Jie, Ji, Xinya, Hao, Wenli, Wang, Junguo, Zhu, Chengwen, Yang, Ye, Gu, Yajun, Qian, Xiaoyun, Yu, Chenjie, Gao, Xia

Issue&Volume: 2024-04-09

Abstract: Deafness is the prevailing sensory impairment among humans, impacting every aspect of one's existence. Half of congenital deafness cases are attributed to genetic factors. Studies have shown that Luzp2 is expressed in hair cells (HCs) and supporting cells of the inner ear, but its specific role in hearing remains unclear. To determine the importance of Luzp2 in auditory function, we generated mice deficient in Luzp2. Our results revealed that Luzp2 has predominant expression within the HCs and pillar cells. However, the loss of Luzp2 did not result in any changes in auditory threshold. HCs or synapse number and HC stereocilia morphology in Luzp2 knockout mice did not show any notable distinctions. This was the first study of the role of Luzp2 in hearing in mice, and our results provide important guidance for the screening of deafness genes.

DOI: 10.1007/s12264-024-01202-5

Source: https://link.springer.com/article/10.1007/s12264-024-01202-5