2024年5月15日，南开大学化学学院Youai Qiu团队在《中国化学》杂志发表论文，综述了烯烃与CO₂光化学/电化学羧化反应的研究进展。

在合成化学中，CO₂是一种丰富、无毒、可再生的C1原料。结合二氧化碳，直接羧基化容易得到的烯烃被认为是一个有前途的策略，以获得高附加值的羧酸并实现二氧化碳固定。然而，由于CO₂的热力学稳定性和动力学惰性以及难以控制区域选择性，烯烃与CO₂的羧化反应仍然是一个挑战。烯烃自由基型功能化代表了一个强大的方式，并使该领域的新反应不断出现。

近年来，新技术的进步，如光氧化还原催化，和有机合成中电化学的复兴，为自由基前体的独特化学反应提供了途径，并为烯烃的功能化提供了新的解决方案。

该文章综述了近十年来烯烃自由基型羧化反应的研究进展，主要是光催化和电催化。该文全面介绍了这些研究进展，总结了目前研究的优点和局限性，并对未来的发展前景进行了展望。

附：英文原文

Title: Recent Advances in Photochemical/Electrochemical Carboxylation of Olefins with CO2

Author: Qian Wang, Yanwei Wang, Min Liu, Ganghui Chu, Youai Qiu

Issue&Volume: 2024-05-15

Abstract: CO2 is an abundant, nontoxic, and renewable C1 feedstock in synthetic chemistry. Direct carboxylation of readily available olefins incorporating CO2 is regarded as a promising strategy to access high value-added carboxylic acids as well as CO2 fixation. However, due to the thermodynamic stability and kinetic inertness of CO2 and the difficulty in controlling the regioselectivity, the carboxylation of olefins with CO2 still remains challenging. Radical-type functionalization with olefins represented a powerful protocol and enabled the development of novel transformations in this realm. More recently, the advance of new technology, such as photoredox catalysis and the renaissance of electrochemistry in organic synthesis, offered access to unique chemical reactivities of radical precursors and provided new solutions to the functionalization of olefins. This review presents the recent advances in the radical-type carboxylation of olefins, which has mainly been achieved through photocatalysis and electrocatalysis in the last decade. In this article, we provide a comprehensive introduction of the progress, summarize the advantages and limitations of current research, and discuss the potential outlook for further development.

DOI: 10.1002/cjoc.202400008

Source: https://onlinelibrary.wiley.com/doi/full/10.1002/cjoc.202400008