西安交通大学Tie-Lin Yang等研究人员合作总结，从临床和遗传学角度揭示治疗精神分裂症的前景看好的神经影像生物标记物。2024年5月4日，《神经科学通报》杂志在线发表了这项成果。

据了解，精神分裂症是一种复杂而严重的脑部疾病。神经科学家对使用基于磁共振的脑IDP来研究精神疾病的病因越来越感兴趣。IDP在识别大脑异常方面具有宝贵的临床优势和生物学意义。

附：英文原文

Title: Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives

Author: Guo, Jing, He, Changyi, Song, Huimiao, Gao, Huiwu, Yao, Shi, Dong, Shan-Shan, Yang, Tie-Lin

Issue&Volume: 2024-05-04

Abstract: Schizophrenia is a complex and serious brain disorder. Neuroscientists have become increasingly interested in using magnetic resonance-based brain imaging-derived phenotypes (IDPs) to investigate the etiology of psychiatric disorders. IDPs capture valuable clinical advantages and hold biological significance in identifying brain abnormalities. In this review, we aim to discuss current and prospective approaches to identify potential biomarkers for schizophrenia using clinical multimodal neuroimaging and imaging genetics. We first described IDPs through their phenotypic classification and neuroimaging genomics. Secondly, we discussed the applications of multimodal neuroimaging by clinical evidence in observational studies and randomized controlled trials. Thirdly, considering the genetic evidence of IDPs, we discussed how can utilize neuroimaging data as an intermediate phenotype to make association inferences by polygenic risk scores and Mendelian randomization. Finally, we discussed machine learning as an optimum approach for validating biomarkers. Together, future research efforts focused on neuroimaging biomarkers aim to enhance our understanding of schizophrenia.

DOI: 10.1007/s12264-024-01214-1

Source: https://link.springer.com/article/10.1007/s12264-024-01214-1